ChemicalBook CAS DataBase List Furo[2,3-c]pyridin-3(2H)-one (9CI)

Furo[2,3-c]pyridin-3(2H)-one (9CI) synthesis

4synthesis methods

Product Name:Furo[2,3-c]pyridin-3(2H)-one (9CI)
CAS Number:106531-52-6
Molecular formula:C7H5NO2
Molecular Weight:135.12

ETHYL 3-HYDROXYFURO[2,3-C]PYRIDINE-2-CARBOXYLATE

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106531-52-6
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Yield:-

Reaction Conditions:

with hydrogenchloride in lithium hydroxide monohydrate;Reflux;

Steps:

A.2.4.3 A.2.4.3 Synthesis of furo[2,3-c]pyridin-3(2H)-one

General procedure: A suspension of 3-hydroxyfuro[2,3-c]pyridine-2-carboxylic acid ethyl ester (10 mmol) in 10 mL 25% HCI solution and 5 mL H₂0 was heated to reflux overnight. After cooling to RT, the reaction mixture was quenched with sat. aq. NaHC0₃ solution and extracted with EtOAc. The combined organic layers were dried over MgS0₄ and concentrated in vacuo to give the desired product as brown solid; LC-MS (A): t_R = 0.13 min; [M+H]+: 136.26.

References:

WO2013/14587,2013,A1 Location in patent:Page/Page column 69-70

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References

3-Hydroxypyridine-4-carboxylic acid ethyl ester

18342-97-7
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106531-52-6
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References

ethyl 3-(2-ethoxy-2-oxoethoxy)isonicotinate

18343-02-7
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106531-52-6
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References