Guaifenesin synthesis
- Product Name:Guaifenesin
- CAS Number:93-14-1
- Molecular formula:C10H14O4
- Molecular Weight:198.22
556-52-5
249 suppliers
$17.67/1gm:
90-05-1
735 suppliers
$5.00/1g
14007-09-1
64 suppliers
$281.00/50mg
93-14-1
572 suppliers
$5.00/5g
Yield:93-14-1 95% ，14007-09-1 5%
Reaction Conditions:
with calcined hydrotalcite in tetrahydrofuran at 120; for 4 h;Kinetics;Autoclave;Reagent/catalyst;Temperature;
Steps:
2.2. Reaction procedure
In a typical reaction, autoclave reactor (details included in sup-porting information) was charged with guaiacol (0.0081 mol), gly-cidol (0.020 mol), tetrahydrofuran (THF) (10 mL) and 0.03 g mL-1(0.9 g) of the catalyst. The total organic phase volume was made to30 mL with THF. An initial sample was taken at the desired temperature. The reaction mixture was stirred with mechanical stirrer atthe desired speed, and samples were collected periodically. For control reaction, speed of agitation was 1000 rpm and temperature was 120°C at self-generated pressure. Reaction samples were analyzed by HPLC (details included in supporting information). Synthesis of guaifenesin (3-(2-methoxyphenoxy)propane-1,2-diol) andbyproduct (2-(2-methoxyphenoxy)propane-1,3-diol) from condensation reaction of guaiacol and glycidol is shown in Scheme 1.
References:
Bhanawase, Shivaji L.;Yadav, Ganapati D. [Catalysis Today,2017,vol. 291,p. 213 - 222]
2210-74-4
301 suppliers
$6.00/250mg
93-14-1
572 suppliers
$5.00/5g
90-05-1
735 suppliers
$5.00/1g
93-14-1
572 suppliers
$5.00/5g