HEXAFLUOROISOPROPYL TOSYLATE synthesis
- Product Name:HEXAFLUOROISOPROPYL TOSYLATE
- CAS Number:67674-48-0
- Molecular formula:C10H8F6O3S
- Molecular Weight:322.22
Yield: 48%
Reaction Conditions:
with [bis(acetoxy)iodo]benzene at 20; for 0.25 h;
Steps:
a) General procedure for the formation of sulfonate 4
General procedure: Iodobenzene diacetate (DIB, 0.24 mmol, 1.2 equiv) was added at room temperature to avigorously stirred solution of dichloromethane (0.5 mL), alcohol (0.5 mL), sulfinate (0.2mmol, 1 equiv) and acetic acid (0.01 to 0.05 mL) or TBAC (55.5 mg, 0.2 mmol, 2 equiv) tosolve the sulfonate salt. The mixture was then stirred for 15 min (followed by TLC with amixture of acetic acid/ethyl acetate/hexane) and then filtered on silica with ethyl acetate.The residue was purified by silica gel chromatography with a mixture of ethylacetate/hexane to give sulfonate product 4, 6 and 8.
References:
Deruer, Elsa;Hamel, Vincent;Blais, Samuel;Canesi, Sylvain [Beilstein Journal of Organic Chemistry,2018,vol. 14,p. 1203 - 1207] Location in patent:supporting information
