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ChemicalBook CAS DataBase List Isoconazole

Isoconazole synthesis

7synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: sodium hydride / 1,4-dioxane; mineral oil / 1 h / 20 °C / Inert atmosphere; Reflux
1.2: Inert atmosphere; Reflux
2.1: nitric acid / acetone / 12 h

References:

Dulcevscaia, Galina M.;Kravtsov, Victor Ch.;Macaev, Fliur Z.;Duca, Gheorghe G.;Stingachi, Eugenia P.;Pogrebnoi, Serghei I.;Boldescu, Veaceslav V.;Clapco, Steliana F.;Tiurina, Janeta P.;Deseatnic-Ciloci, Alexandra A.;Lipkowski, Janusz;Liu, Shi-Xia;Decurtins, Silvio;Baca, Svetlana G. [Polyhedron,2013,vol. 52,p. 106 - 114]

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