Isotanshinone IIA synthesis

Yield:-

Steps:

Multi-step reaction with 3 steps
1: 95.3 percent / N-bromosuccinimide; triphenylphosphine; pyridine / CH₂Cl₂ / 240 h / 20 °C
2: 66.4 percent / potassium nitroso disulfonate / aq. phosphate buffer; acetonitrile / 5.5 h / 20 °C / pH 7
3: 12.7 percent / pyridine / benzene / 48 h / Heating

References:

Marrero, Joaquin Gonzalez;Andres, Lucia San;Luis, Javier Gutierrez [Chemical and Pharmaceutical Bulletin,2005,vol. 53,# 12,p. 1524 - 1529]

FullText