ChemicalBook CAS DataBase List L-Asparagine

L-Asparagine synthesis

8synthesis methods

Product Name:L-Asparagine
CAS Number:70-47-3
Molecular formula:C4H8N2O3
Molecular Weight:132.12

A simple synthesis of L -asparagine starts from L -aspartic acid which is esterified to the b-methyl ester followed by treatment with ammonia.

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Yield:70-47-3 75%

Reaction Conditions:

with ammonium hydroxide at 30; under 750.075 Torr; for 9 h;Reagent/catalyst;Temperature;Pressure;

Steps:

1-3; 1; 2

Step 4, acylation reaction: 3000 kg of L-aspartic acid methyl ester hydrochloride obtained in the third step is put into the reaction kettle, and then 1700 kg of 30% ammonia water is pumped into the reaction kettle, and then reacted at 0.1 MPa and 30 ° C for 9 hours. L-asparagine is obtained.Step 5, re-distillation: distilling the material obtained in the fourth step under normal pressure at 30 ° C, distilling off excess ammonia and water, and applying ammonia water to obtain a crystallization yield of L-aspartic acid amine of 75%.Step 6: recrystallization: the L-aspartic acid amine crystal obtained by the step 5 distillation is centrifuged at 6000 r/min for 40 minutes to obtain a finished product of L-asparagine.The effective content of L-asparagine is 85%.The water content is 18%.

References:

CN109678740,2019,A Location in patent:Page/Page column 4-6

71989-16-7 Synthesis