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ChemicalBook CAS DataBase List Lafutidine

Lafutidine synthesis

7synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: 91 percent / tetrahydrofuran / 18 h / Ambient temperature
2: 52 percent / p-TsOH, H2O / acetone / 18 h / Heating
3: 2.) NaBH4 / 1.) EtOH, 3 h, 2.) EtOH, 16 h

References:

Hirakawa, Nobuhiko;Matsumoto, Hajime;Hosoda, Akihiko;Sekine, Akihiro;Yamaura, Tetsuaki;Sekine, Yasuo [Chemical and Pharmaceutical Bulletin,1998,vol. 46,# 4,p. 616 - 622]

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