ChemicalBook CAS DataBase List METHYL 1H-PYRROLO[3,2-B]PYRIDINE-5-CARBOXYLATE

METHYL 1H-PYRROLO[3,2-B]PYRIDINE-5-CARBOXYLATE synthesis

6synthesis methods

Product Name:METHYL 1H-PYRROLO[3,2-B]PYRIDINE-5-CARBOXYLATE
CAS Number:872355-63-0
Molecular formula:C9H8N2O2
Molecular Weight:176.17

2-Pyridinecarboxylic acid, 5-(acetylamino)-6-[2-(trimethylsilyl)ethynyl]-, methyl ester

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METHYL 1H-PYRROLO[3,2-B]PYRIDINE-5-CARBOXYLATE

872355-63-0
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Yield:-

Reaction Conditions:

with tetrabutyl ammonium fluoride in tetrahydrofuran at 70; for 4 h;

Steps:

11.F

Tetrabutylammonium fluoride (6 mL, 1.0 M in THF) was added to the tetrahydrofuran (7 mL) solution of 5-acetylamino-5-trimethylsilanylethynyl-2 -nicotinic acid methyl ester (1.46 g). The reaction was stirred at 70 ⁰C for 4 h then the reaction mixture was cooled to room temperature and was concentrated. The residue obtained was diluted with water. The solid thus separated was filtered and was washed with water. The solid was dried under high vacuum and was used as such for the next step without any purification (Yield: 0.69 g, R_f: 0.37 min, Condition B, M+H⁺: 177).

References:

WO2006/112828,2006,A1 Location in patent:Page/Page column 83

24242-20-4 Synthesis