Phenacetin synthesis
- Product Name:Phenacetin
- CAS Number:62-44-2
- Molecular formula:C10H13NO2
- Molecular Weight:179.22
Yield:62-44-2 94%
Reaction Conditions:
with dipotassium peroxodisulfate in water at 100; for 0.166667 h;Microwave irradiation;Green chemistry;
Steps:
General procedure for microwave reaction
General procedure: Amide (1.0 mmol), amine (1.0 mmol) and K2S2O8 (1.5 mmol) were charged in microwave vial added water (2.0 mL), the reaction mixture was treated at 100°C and 100W for 10 min. After the complete conversion (by TLC) of the amine, distilled water (10 mL) was added and extracted with ethyl acetate (2 ×10 mL). The combined organic phase was dried over Na2SO4, and then concentrated using rotary vacuum evaporator. The crude product was purified by column chromatography (30% Ethyl acetate/hexane) to get pure compound.
References:
Srinivas, Mahesuni;Hudwekar, Abhinandan D.;Venkateswarlu, Vunnam;Reddy, G. Lakshma;Kumar, K. A. Aravinda;Vishwakarma, Ram A.;Sawant, Sanghapal D. [Tetrahedron Letters,2015,vol. 56,# 33,p. 4775 - 4779] Location in patent:supporting information
1676-63-7
261 suppliers
$6.00/1g
62-44-2
502 suppliers
$20.00/25g
