ChemicalBook CAS DataBase List Phenolphthalein

Phenolphthalein synthesis

8synthesis methods

Product Name:Phenolphthalein
CAS Number:77-09-8
Molecular formula:C20H14O4
Molecular Weight:318.32

85-44-9 Synthesis

85-44-9
751 suppliers
$9.00/5g

108-95-2 Synthesis

108-95-2
718 suppliers
$14.00/25g

77-09-8
531 suppliers
$10.00/5g

Yield:77-09-8 90%

Reaction Conditions:

with mixed metal catalyst derived from Thlaspi at 80; for 0.0833333 h;Friedel-Crafts Acylation;

Steps:

3.3.1.3.1.2 Phenolphthalein

500 mg of phthalic anhydride, 500 mg of phenol and 1 g of crude catalyst derived from Thlaspi (Example 1.1, 12N HCl) dehydrated at 110° C. for a few minutes are placed in a single-necked flask and heated at 80° C. for 5 minutes. (0510) After cooling down, the reaction mixture is diluted in 5 mL of a water/ethanol mixture. 1 mL of solution is taken then added to a 3M soda solution. (0511) In the case of phenolphthalein, the solution becomes pink immediately. (0512) After washing with ether, the phenolphthalein crystallizes easily.

References:

US9149796,2015,B2 Location in patent:Page/Page column 41

85-44-9 Synthesis

85-44-9
751 suppliers
$9.00/5g