Sodium D-pantothenate synthesis

Yield:867-81-2 76.3 g

Reaction Conditions:

in ethanol for 3 h;Reflux;

Steps:

1 Comparative Example 1 Preparation of sodium D-pantothenate crystals described in GB565976
55.5 g of sodium β-alaninate,Pantolactone 65 grams,Dissolved in 350 ml of absolute ethanol,Heated to reflux for 3 hours,Filtered while still hotThe reaction vessel was washed with 50 ml of ethanol,After the washing solution was filtered and the reaction mixture was combined,The filtrate was placed at 0 for 5 days,Filter, wash the solid with a little ethanol,Drying to constant weight at room temperature under reduced pressure,Got 76.3 grams of white crystalline powder,Which is the sodium D-pantothenate crystal described in GB565976.

References:

Chengdu Qiaofeng Science And Technology Co., Ltd.;Li Peng CN104761463, 2017, B Location in patent:Paragraph 0032; 0033

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