Triamterene synthesis
- Product Name:Triamterene
- CAS Number:396-01-0
- Molecular formula:C12H11N7
- Molecular Weight:253.26
Yield:396-01-0 85.7%
Reaction Conditions:
with sodium ethanolate;sodium hydroxide in ethanol;N,N-dimethyl acetamide at 90 - 100;Reagent/catalyst;
Steps:
1 The method of producing the triamterene, Characterized in that the preparation method comprises the following steps:
To the reaction kettle into the 400kg reaction with DMAC, 100kg 5-nitroso-2,4,6-triaminopyrimidine,120kgPhenylacetonitrile,5kg solid sodium hydroxide, stir, at 20-30 ° C, start dropping37kgEthanol sodium ethanol solution,1-2h drops finished, after the drop slowly heated to 90-100 ° C, 5h after the insulation after cooling to 30 ° C, the material was filtered to remove the crude albendrobin crude. refined The crude dibenzopropenidine crude product into the refining kettle, put 1200kg refined with DMAC, stirring up to 110-120 ° C, filtered while hot, the filtrate into the crystallization kettle, the filtrate cooled to 20-25 ° C, filtered and dried, the ammonia benzene dish 140.8kg, the yield of 85.7%, content of 99.64%
References:
Yancheng Maidike Chemicals To Make Co., Ltd.;Yu Suogeng;Yan Zhengming;Yang Yong CN106967069, 2017, A Location in patent:Paragraph 0022-0039
54-31-9
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$22.00/1g
396-01-0
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$15.00/1g