| Identification | More | [Name]
Butyryl chloride | [CAS]
141-75-3 | [Synonyms]
AKOS BBS-00003913
BUTANOYL CHLORIDE
BUTYRIC ACID CHLORIDE
BUTYROYL CHLORIDE
BUTYRYL CHLORIDE
N-BUTANOYL CHLORIDE
N-BUTYRIC ACID CHLORIDE
N-BUTYROYL CHLORIDE
N-BUTYRYL CHLORIDE
TETRANOYL CHLORIDE
Butyric chloride
butyricchloride
butyryl
Butyrylchlorid
BUTYRYL CHLORIDE, 99+%
N-Butyryl
N-BUTYLVINYLETHER
BUTYRYL CHLORIDE extrapure | [EINECS(EC#)]
205-498-5 | [Molecular Formula]
C4H7ClO | [MDL Number]
MFCD00000752 | [Molecular Weight]
106.55 | [MOL File]
141-75-3.mol |
| Chemical Properties | Back Directory | [Appearance]
Clear slightly yellow liquid | [Melting point ]
−89 °C(lit.)
| [Boiling point ]
102 °C(lit.)
| [density ]
1.026 g/mL at 25 °C(lit.)
| [vapor density ]
3.7 (vs air)
| [vapor pressure ]
39 hPa (20 °C) | [refractive index ]
n20/D 1.412(lit.)
| [RTECS ]
EM0595000 | [Fp ]
71 °F
| [storage temp. ]
Flammables area | [solubility ]
Miscible with ether. | [form ]
Liquid | [color ]
Clear slightly yellow | [Odor]
pungent odor | [explosive limit]
2.5-7.3%(V) | [Water Solubility ]
decomposes | [FreezingPoint ]
-89℃ | [Sensitive ]
Moisture Sensitive | [Merck ]
14,1598 | [BRN ]
605395 | [InChIKey]
DVECBJCOGJRVPX-UHFFFAOYSA-N | [LogP]
0.51 at 25℃ | [CAS DataBase Reference]
141-75-3(CAS DataBase Reference) | [NIST Chemistry Reference]
Butanoyl chloride(141-75-3) | [EPA Substance Registry System]
Butanoyl chloride (141-75-3) |
| Safety Data | Back Directory | [Hazard Codes ]
F,C | [Risk Statements ]
R11:Highly Flammable.
R34:Causes burns. | [Safety Statements ]
S16:Keep away from sources of ignition-No smoking .
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 2353 3/PG 2
| [WGK Germany ]
1
| [F ]
13 | [Autoignition Temperature]
280 °C | [TSCA ]
Yes | [HazardClass ]
3 | [PackingGroup ]
II | [HS Code ]
29159000 | [Hazardous Substances Data]
141-75-3(Hazardous Substances Data) |
| Hazard Information | Back Directory | [General Description]
A clear colorless liquid with a sharp odor. Slightly denser than water. Flash point near 20°F. Severely irritates skin, eyes, and mucous membranes. Used to make other chemicals. | [Reactivity Profile]
BUTYRYL CHLORIDE(141-75-3) slowly dissolves in water with decomposition and formation of a weakly acidic solution. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291]. | [Air & Water Reactions]
Highly flammable. Fumes in air. Decomposes exothermically in water to give corrosive hydrochloric acid. | [Health Hazard]
Extremely destructive to the mucous membranes, upper respiratory tract, eyes, and skin. Inhalation may cause death as a result of spasm, inflammation and edema of the larynx and bronchi, chemical pneumonitis, and pulmonary edema. Symptoms of exposure include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting. | [Fire Hazard]
Special Hazards of Combustion Products: Emits toxic fumes of chlorine gas | [Chemical Properties]
Butyryl chloride is a colorless to light yellow liquid with a strong pungent odor. It undergoes vigorous hydrolysis with water; decomposes in water; soluble in almost aprotic organic solvents. It is used as an intermediate for organic synthesis for the preparation of pharmaceuticals, agrochemicals, dyes, cellulose esters, and peroxide compounds. | [Uses]
Butyryl chloride has been used to esterify wood meal dissolved in the ionic liquid, 1-butyl-3-methylimidazolium chloride. | [Uses]
Butyryl chloride is used as an intermediate for the synthesis of active pharmaceutical ingredients benzoyl peroxide, t-butyl perbenzoate, and benzophenone. It is also used as an acylation reagent. Further, it is used in the preparation of peroxides such as benzoyl peroxide, benzophenone and t-butyl perbenzoate. In addition to this, it is involved in the preparation of chromones and antiproliferative agents.
Butyryl chloride has been used to esterify wood meal dissolved in the ionic liquid, 1-butyl-3-methylimidazolium chloride. | [Flammability and Explosibility]
Flammable | [Purification Methods]
Check IR to see if there is a significant peak at 3000-3500 cm-1 (br) for OH. If OH is present then reflux with less than one mole equivalent of SOCl2 for 1hour and distil directly. The fraction boiling between 85-100o is then refractionated at atmospheric pressure. Keep all apparatus free from moisture and store the product in sealed glass ampoules under N2. LACHRYMATORY; handle in a good fume hood. [Hefferich & Schaeffer Org Synth Coll Vol I 147 1941, Beilstein 2 IV 803.] |
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