| Identification | More | [Name]
7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL | [CAS]
18000-24-3 | [Synonyms]
7-CKA
7-CL-KYNA
7-CHLOROKYNURENIC ACID
7-Chloroquinurenic acid
7-Chlorokynurenic acid (7-CKA)
7-CHLOROKYNURENIC ACID HYDROCHLORIDE
7-Chloro-4-hydroxy-2-quinolinecarboxylic acid
7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID
7-chloro-4-oxo-1H-quinoline-2-carboxylic acid
7-chloro-4-keto-1H-quinoline-2-carboxylic acid
2-Quinolinecarboxylic acid, 7-chloro-4-hydroxy-
7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL
7-Chloro-4-hydroxyquinoline-2-carboxylic acid, 7-Cl-KYNA
7-Chloro-4-hydroxyquinoline-2-carboxylic acid hydrochloride | [EINECS(EC#)]
241-913-6 | [Molecular Formula]
C10H7Cl2NO3 | [MDL Number]
MFCD00674924 | [Molecular Weight]
260.07 | [MOL File]
18000-24-3.mol |
| Chemical Properties | Back Directory | [Melting point ]
277-278 °C (decomp) | [Boiling point ]
461.5±45.0 °C(Predicted) | [density ]
1.600±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
0.1 M NaOH: 13.7 mg/mL
| [form ]
solid
| [pka]
0.90±0.30(Predicted) | [color ]
tan
| [CAS DataBase Reference]
18000-24-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
|
| Hazard Information | Back Directory | [Uses]
NMDA receptor antagonist at the glycine site | [Definition]
ChEBI: A quinolinemonocarboxylic acid that is quinaldic acid which is substituted by a hydroxy group at position 4 and by a chlorine at position 7. It is a potent NMDA glutamate receptor antagonist which antagonizes the strychnine-insensitive glycine site of the
MDA receptor. It also prevents neurodegeneration produced by quinolinic acid. | [Biological Functions]
Glycine B agonist site antagonist of N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid is also a potent inhibitor of glutamate reuptake into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid has potent analgesic effects in neurotransmission. | [Biological Activity]
NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles. Also available as part of the NMDA Receptor - Glycine Site Tocriset™ . | [in vivo]
Male Sprague-Dawley rats pretreated with 7-Chlorokynurenic acid (10 nM) shows a significant retardation of development of both the electroencephalographic and motor (17.7±2.9 daily stimulations) components of the seizure response. | [storage]
Room temperature |
|
| Company Name: |
Shanghai Uchem Inc.
|
| Tel: |
15618758386 15618758386 |
| Website: |
www.chemicalbook.com/showsupplierproductslist15300/0.htm |
| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
|