| Identification | More | [Name]
1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE | [CAS]
25371-96-4 | [Synonyms]
1-[2-(TRIFLUOROMETHYL)PHENYL]-1H-IMIDAZOLE
1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE
1-(ALPHA,ALPHA,ALPHA-TRIFLUORO-O-TOLYL)-IMIDAZOLE
I-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE
TRIM
1-[2-(Trifluoromethyl)phenyl]-1H-imidazole 98%
1-[2-(Trifluoromethyl)phenyl]-1H-imidazole98%
1-(2-Trifluoromethylphenyl)imidazole, 98+% | [EINECS(EC#)]
636-734-9 | [Molecular Formula]
C10H7F3N2 | [MDL Number]
MFCD00041206 | [Molecular Weight]
212.17 | [MOL File]
25371-96-4.mol |
| Chemical Properties | Back Directory | [Melting point ]
43 °C | [Boiling point ]
75°C 0,02mm | [density ]
1.3253 (estimate) | [Fp ]
75°C/0.025mm | [storage temp. ]
2-8°C
| [solubility ]
Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 20 mg/ml). | [form ]
White solid. | [pka]
4.96±0.10(Predicted) | [color ]
White | [Sensitive ]
Light Sensitive | [BRN ]
3955637 | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. | [CAS DataBase Reference]
25371-96-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT, LIGHT SENSITIVE | [HS Code ]
29339900 |
| Hazard Information | Back Directory | [Description]
TRIM (25371-96-4) is a potent inhibitor of neuronal and inducible nitric oxide synthases, (IC50?= 28.2 and 27.0 μM respectively). Inhibits endothelial NOS with lower potency (IC50 = 1057.5 μM).1?TRIM displays antinociceptive activity?in vivo.2 | [Uses]
TRIM is a potent inhibitor of neuronal nitric oxide synthase in vitro, in animal models. | [Definition]
ChEBI: 1-[2-(trifluoromethyl)phenyl]imidazole is a member of imidazoles. | [Biological Activity]
A potent inhibitor of neuronal and inducible NO synthases, with much lower affinity for the endothelial isoform (displays IC 50 values of 28.2, 27.0 and 1057.5 μ M respectively). Antinociceptive in vivo . | [Biochem/physiol Actions]
Potent nitric oxide synthase inhibitor. Because of the putative involvement of nitric oxide in depression and stress syndromes, TRIM was studied for its antidepressant effects, and found to reduce manifestations of stress in an animal model as well as fluoxetine. | [storage]
Store at RT | [References]
1) Handy?et al. (1995), The antinociceptive effect of 1-(2-trifluoromethylphenyl)imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse; Br. J. Pharmacol.,?116?2349
2) Handy?et al. (1996),?Inhibition of nitric oxide synthase by 1-(2-trifluoromethylphenyl) imidazole (TRIM) in vitro: antinociceptive and cardiovascular effects; Br. J. Pharmacol.,?119?423 |
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| Company Name: |
Alfa Aesar
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| Tel: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Spectrum Chemical Manufacturing Corp.
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| Tel: |
021-021-021-67601398-809-809-809 15221380277 |
| Website: |
www.spectrumchemical.com/oa_html/index.jsp?minisite=10020&respid=22372&language=us |
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