| Identification | Back Directory | [Name]
Diminutol | [CAS]
361431-33-6 | [Synonyms]
NG72
Diminutol
1-Butanol, 2-[[6-[(3-aminophenyl)thio]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-, (2R)- | [Molecular Formula]
C19H26N6OS | [MDL Number]
MFCD23160286 | [MOL File]
361431-33-6.mol | [Molecular Weight]
386.51 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml; Ethanol: 20 mg/ml | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Description]
Diminutol is a cell-permeable purine derivative that inhibits the NADP-dependent oxidoreductase, NQO1 (Ki = 1.72 μM), to destabilize microtubules and disrupt mitosis. At 50 μM, it directly affects tubulin polymerization in Xenopus egg extracts without interfering with the activity of Cdk1, DNA replication, or actin polymerization. | [Uses]
Diminutol is a cell-permeable purine analog that inhibits NQ01 and blocks mitotic spindle assembly. | [Uses]
Diminutol is a cell-permeable purine derivative that inhibits the NADP-dependent oxidoreductase, NQO1 (Ki = 1.72 μM), to destabilize microtubules and disrupt mitosis. At 50 μM, it directly affects tubulin polymerization in Xenopus egg extracts without interfering with the activity of Cdk1, DNA replication, or actin polymerization.[Cayman Chemical] | [storage]
Store at -20°C |
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DC Chemicals
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Energy Chemical
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