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361431-33-6 Basic information More..
Product Name:Diminutol
Synonyms:Diminutol;1-Butanol, 2-[[6-[(3-aminophenyl)thio]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-, (2R)-;NG72
CAS:361431-33-6
MF:C19H26N6OS
MW:386.51
EINECS:
Mol File:361431-33-6.mol
361431-33-6

Use

Diminutol is a cell-permeable purine derivative that inhibits the NADP-dependent oxidoreductase, NQO1 (Ki = 1.72 μM), to destabilize microtubules and disrupt mitosis. At 50 μM, it directly affects tubulin polymerization in Xenopus egg extracts without interfering with the activity of Cdk1, DNA replication, or actin polymerization.[Cayman Chemical]

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