| Identification | More | [Name]
DL-BUTHIONINE-[S,R]-SULFOXIMINE | [CAS]
5072-26-4 | [Synonyms]
DL-BUTHIONINE (R,S)-SULFOXIMINE
DL-BUTHIONINE-[S,R]-SULFOXIMINE
DL-BUTHIONINE (S,R)-SULPHOXIME
DL-BUTHIONINE-SULFOXIMINE
2-amino-4-(s-butylsulfonimidoyl)-butanoicaci
2-amino-4-(s-butylsulfonimidoyl)butanoicacid
buthioninesulfoxamine
buthioninesulfoximine
buthioninesulphoximine
butioninesulfoximine
s-(3-amino-3-carboxypropyl)-s-butyl-sulfoximin
Butanoic acid, 2-amino-4-(S-butylsulfonimidoyl)-.
NSC 381100
S-(3-Amino-3-carboxypropyl)-S-butylsulfoximine
2-Amino-4-(S-butylsulfonimidoyl)butyric acid | [EINECS(EC#)]
246-685-1 | [Molecular Formula]
C8H18N2O3S | [MDL Number]
MFCD00070309 | [Molecular Weight]
222.31 | [MOL File]
5072-26-4.mol |
| Chemical Properties | Back Directory | [Appearance]
White Crystalline Solid | [Melting point ]
215 °C (dec.)(lit.) | [Boiling point ]
382.3±52.0 °C(Predicted) | [density ]
1.29±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C
| [solubility ]
H2O: 50 mg/mL, clear, colorless
| [form ]
Fluffy Powder | [color ]
White | [Usage]
A potent and specific inhibitor of alpha-glutamyl cysteine synthetase | [Merck ]
13,1520 | [BRN ]
2367136 | [CAS DataBase Reference]
5072-26-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
EK7713435
| [F ]
10 | [HS Code ]
29309090 |
| Hazard Information | Back Directory | [Chemical Properties]
White Crystalline Solid | [Uses]
DL-Buthionine-sulfoximine is suitable for use to:
- examine whether the inhibition of glutathione by BSO enhances the apoptotic effect of estrogen on antihormone-resistant human breast cancer cells
- investigate the effect of BSO on development of bovine embryos
- inhibit GSH in several studies
- investigate the effect of GSH synthesis on oocyte maturation
It may be used to inhibit GSH and evaluate the hepatotoxicity and nephrotoxicity of natural food colorants in the absence of GSH | [Uses]
A potent and specific inhibitor of alpha-glutamyl cysteine synthetase | [Uses]
Biological tool for depletion of glutathione. | [Definition]
ChEBI: A sulfoximide that is the sulfoximine derivative of an analogue of DL-methionine in which the S-methyl group is replaced by S-butyl. | [General Description]
DL-buthionine-SR-sulfoximine (BSO) is an amino acid analogue, which acts as an inhibitor of γ-glutamylcysteine synthetase. BSO increases the sensitivity of Trypanosoma cruzi to antiparasitic drugs, such as nifurtimox or benznidazole. | [Biochem/physiol Actions]
DL-Buthionine-sulfoximine inhibits the biosynthesis of Glutathione (GSH) in liver and other peripheral organs. It does not have any effect on GSH in the CNS. It augments the antiproliferative action of reactive oxygen species (e.g., hydrogen peroxide), and agents that indirectly cause accumulation of reactive oxygen species (e.g., 2-methoxyestradiol, which increases intracellular superoxide anion). |
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Sigma-Aldrich
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