| Identification | More | [Name]
2-CHLORO-ALPHA-[2-DIMETHYLAMINOETHYL]BENZHYDROL HYDROCHLORIDE | [CAS]
511-13-7 | [Synonyms]
2-CHLORO-ALPHA-[2-DIMETHYLAMINOETHYL]BENZHYDROL HYDROCHLORIDE
CHLOPHEDIANOL
CHLOPHEDIANOL HYDROCHLORIDE
1-o-chlorophenyl-1-phenyl-3-dimethylamino-1-propanolhydrochloride
2-Chloro-[2-(dimethylamino)ethyl]-Phenyl-benzenemethanolhydrochloride
2-chloro-alpha-(2-(dimethylamino)ethyl)-alpha-phenyl-benzenemethanohydro
2-chloro-alpha-(2-(dimethylamino)ethyl)-benzhydrohydrochloride
2-chloro-alpha-[2-(dimethylamino)ethyl]-alpha-phenyl-benzenemethanohydro
alpha-(2-dimethylaminoethyl)-o-chlorobenzhydrolhydrochloride
bayer-186
bayerb-186
chlorphedianol,hydrochloride
clofedanolhydrochloride
clophedianolhydrochloride
coldrin
detigon
detigon-bayer
pectolitan
refugal
sk74 | [EINECS(EC#)]
208-124-9 | [Molecular Formula]
C17H21Cl2NO | [MDL Number]
MFCD00079013 | [Molecular Weight]
326.26 | [MOL File]
511-13-7.mol |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
R25:Toxic if swallowed. | [Safety Statements ]
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
3249 | [RTECS ]
DC7600000 | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [Toxicity]
LD50 orally in rats: 350 mg/kg; s.c. in mice: 95 mg/kg (Lorenz) |
| Hazard Information | Back Directory | [Originator]
Abehol,Pliva | [Uses]
A centrally-acting cough suppressant. It has local anesthetic and antihistamine properties, and may have anticholinergic effects at high doses. | [Definition]
ChEBI: Chlophedianol hydrochloride is a diarylmethane. | [Manufacturing Process]
To a suspension of 330.0 g of sodamide (moistened with toluene) in 1500 ml
of absolute ether, a solution of 1080.0 g of o-chlorobenzophenone and 350.0
g of acetonitrile in 3500 ml of absolute ether was gradually added dropwise,
with stirring, such that the reaction temperature adjusted itself to 28°-30°C.
The reaction mixture was stirred for 12 to 15 h at room temperature and was
then added carefully to some ice water. The resulting solution was extracted 3
times with ether. The ether solution was washed with water, dried over
Na2SO4, filtered, and finally concentrated. When 1 L of petroleum ether was
added, 1240.0 g (96% of theoretical) of β-phenyl-β-o-chlorophenylhydroacrylonitrile (melting point 90°-92°C) precipitated.
500.0 g of the β-phenyl-β-o-chlorophenyl-hydroacrylonitrile were dissolved in
3 L of methanol and hydrogenated in the presence of 50.0 g of Raney cobalt
at a temperature of 60°-70°C and a pressure of 80-85 ATM. Two moles of
hydrogen were absorbed, and after separation of the methanolic solution from
the catalyst, 450.0 g of 1-o-chlorophenyl-1-phenyl-3-aminopropanol-1 of
melting point 117°C were obtained.
Catalytic methylation of 1-o-chlorophenyl-1-phenyl-3-aminopropanol-1
(hydrogenation in the presence of 2.2 mol of formaldehyde in aqueous
methanol with Raney nickel catalyst) yielded 450.0 g of l-o-chlorophenyl-1-
phenyl-3 dimethylaminopropanol-1 of melting point 120°C.
In practice it is usually used as hydrochloride. | [Brand name]
Ulo (3M
Pharmaceuticals). | [Therapeutic Function]
Antitussive |
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