| Identification | More | [Name]
Naloxone hydrochloride dihydrate | [CAS]
51481-60-8 | [Synonyms]
4,5alpha-epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one hydrochloride dihydrate
NALOXONE HYDROCHLORIDE, DIHYDRATE
naloxone F&D version of N7758
Naloxone HCl dihydrate
NALOXONE F&D VERSION OF N7758 FOR &
NALOXONE F&D VERSION OF N7758 FOR HUMA&
NaloxonHCl-Dihydrat
NaloxonhydrochloridDihydrat
Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, hydrochloride, dihydrate, (5.alpha.)-
NALOXONEHYDROCHLORIDE,DIHYDRATE,USP
Naloxone dihydrate hydrochloride | [EINECS(EC#)]
206-611-0 | [Molecular Formula]
C19H26ClNO6 | [MDL Number]
MFCD00150901 | [Molecular Weight]
399.87 | [MOL File]
51481-60-8.mol |
| Chemical Properties | Back Directory | [Appearance]
White or almost white, hygroscopic, crystalline powder. | [Melting point ]
182 °C (dec.)(lit.) | [storage temp. ]
2-8°C
| [solubility ]
ethanol: 3.3 mg/mL stable for several months refrigerated if protected from light.
| [form ]
powder
| [color ]
white to off-white
| [optical activity]
[α]25/D 178.6°, c = 2.5 in H2O(lit.) | [Merck ]
13,6388 | [BRN ]
6260807 | [CAS DataBase Reference]
51481-60-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [WGK Germany ]
3
|
| Hazard Information | Back Directory | [Chemical Properties]
White or almost white, hygroscopic, crystalline powder. | [Uses]
Antagonist (to narcotics). | [Uses]
Naloxone Hydrochloride Dihydrate is a specific opioid antagonist. Narcotic antagonist. | [Brand name]
Narcan (Bristol-Myers Squibb); Narcan (Endo). | [Biochem/physiol Actions]
Competitive antagonist for μ, κ, δ, and σ opioid receptors; blocks the action of σ-agonists at opioid sites. Naloxone′s antagonistic effect last for about 45 min and thus, requires repeated dosage. It results in critical side effects such as pulmonary edema. | [Purification Methods]
This opiate antagonist has been recrystallised from EtOH/Et2O or H2O. It is soluble in H2O (5%) and EtOH but insoluble in Et2O. The free base has m 184o (177-178o also reported) after recrystallisation from EtOAc, and [] D -194.5o (c 0.93, CHCl3). [Olofson et al. Tetrahedron Lett 1567 1977, Gold et al. Med Res Rev 2 211 1982.] |
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| Company Name: |
Rusan Pharma Ltd
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| Tel: |
+91-2228687035 +91-9690022465 |
| Website: |
www.rusanpharma.com |
| Company Name: |
Ralington Pharma
|
| Tel: |
+91-7948911722 +91-9687771722 |
| Website: |
www.ralingtonpharma.com |
| Company Name: |
Spectrum Chemical Manufacturing Corp.
|
| Tel: |
021-021-021-67601398-809-809-809 15221380277 |
| Website: |
www.spectrumchemical.com/oa_html/index.jsp?minisite=10020&respid=22372&language=us |
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