| Identification | More | [Name]
2-NITROBENZYL CHLORIDE | [CAS]
612-23-7 | [Synonyms]
2-NITROBENZYL CHLORIDE
A-CHLORO-O-NITROTOLUENE
AKOS BBS-00004020
ALPHA-CHLORO-2-NITROTOLUENE
ALPHA-CHLORO-O-NITROTOLUENE
O-NITROBENZYL CHLORIDE
1-(Chloromethyl)-2-nitrobenzene
1-(chloromethyl)-2-nitro-benzen
1-(chloromethyl)-2-nitrobenzene
alpha-chloro-o-nitro-toluen
Toluene, alpha-chloro-o-nitro-
2-NitrobenzylChloride98%
à-chloro-2-nitrotoluene
α-chloro-2-nitrotoluene
ORTHO-NITROBENZYLCHLORIDE
1-Nitro-2-(chloromethyl)benzene | [EINECS(EC#)]
210-300-5 | [Molecular Formula]
C7H6ClNO2 | [MDL Number]
MFCD00007185 | [Molecular Weight]
171.58 | [MOL File]
612-23-7.mol |
| Chemical Properties | Back Directory | [Appearance]
liquid | [Melting point ]
46-48 °C (lit.) | [Boiling point ]
127-133 °C/10 mmHg (lit.) | [density ]
1,556 g/cm3 | [refractive index ]
1.5557 (estimate) | [Fp ]
>230 °F
| [storage temp. ]
Store below +30°C. | [solubility ]
ethanol: soluble98% | [form ]
Crystals, Crystalline Powder or Chunks | [color ]
Yellow to tan | [Stability:]
Stable. Incompatible with bases, moisture, acohols, oxidizing agents, amines. Corrodes steel. | [Water Solubility ]
Soluble in acetone, alcohol benzene, diethyl ether, and ethanol (98%). Insoluble in water. | [BRN ]
388396 | [CAS DataBase Reference]
612-23-7(CAS DataBase Reference) | [EPA Substance Registry System]
o-Nitrobenzyl chloride (612-23-7) |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns.
R36:Irritating to the eyes. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S27:Take off immediately all contaminated clothing . | [RIDADR ]
UN 3261 8/PG 2
| [WGK Germany ]
3
| [RTECS ]
XS9092000
| [F ]
19-21 | [HazardClass ]
8 | [PackingGroup ]
II | [HS Code ]
29049090 |
| Hazard Information | Back Directory | [General Description]
Pale yellow crystals. Insoluble in water. Is thermally unstable. | [Reactivity Profile]
A halogenated aromatic nitro compound. Aromatic nitro compounds range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction that culminates in a detonation. The aromatic nitro compounds may explode in the presence of a base such as sodium hydroxide or potassium hydroxide even in the presence of water or organic solvents. The explosive tendencies of aromatic nitro compounds are increased by the presence of multiple nitro groups. | [Air & Water Reactions]
Insoluble in water. | [Health Hazard]
ACUTE/CHRONIC HAZARDS: Toxic. Lachrymator. Causes irritation on contact. Hazardous decomposition products. Mutagen. | [Fire Hazard]
This compound is combustible. | [Chemical Properties]
liquid | [Uses]
2-Nitrobenzyl chloride was used in the synthesis of S-(2-nitrobenzyl)cysteine which was inserted into human erythropoietin. 2-Nitrobenzyl chloride was used to prepare 4,4′-dinitrostillbene. | [Uses]
2-Nitrobenzyl chloride has been used to introduce the photo labile 2-nitrobenzyl protecting group for the phenolic OH group of tyrosine. It is used as a pharmaceutical intermediate. | [Biochem/physiol Actions]
2-Nitrobenzyl chloride reacts with N-methyldiethanolamine and further reaction of the resulting quaternary diol with thionyl chloride at room temperature yields nitrobenzyl mustard quaternary salts. |
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