| Identification | More | [Name]
1-(2-Hydroxyethyl)-1-methylguanidine dihydrogen phosphate | [CAS]
6903-79-3 | [Synonyms]
1-(2-hydroxyethyl)-1-methylguanidine dihydrogen phosphate
CREATINOLFOSFATE
creatinol phosphate
CREATINOLO-PHOSPHATE
CREATINOLO-PHOSPHATEANDITSSODIUMSALT
1-[2-(Phosphonooxy)ethyl]-1-methylguanidine
Aplodan
COP | [EINECS(EC#)]
230-011-8 | [Molecular Formula]
C4H12N3O4P | [MDL Number]
MFCD00868297 | [Molecular Weight]
197.13 | [MOL File]
6903-79-3.mol |
| Hazard Information | Back Directory | [Originator]
Aplodan,Simes,Italy,1968 | [Definition]
ChEBI: Creatinolfosfate is a phosphoethanolamine. | [Manufacturing Process]
In a reactor put 80 kg of polyphosphoric acid having the following
composition: H5P3O10 - 60%; (HPO3)6 - 10%; H4P2O7 - 15%; (HPO3)x - 10%;
total content in P2O5 about 83%; this is heated to about 160°C.
Then 360 kg of creatinol phosphate are added to the polyphosphoric acid;
continue to heat for about two hours under vacuum until the reaction water is
eliminated.
The molten mass is then poured into ethanol at 95°C, the solution cooled
down to 10°C and the precipitated product separated by centrifugation. The
resulting product is dissolved in the minimum quantity of warm water and the
solution poured into ethanol.
Thus 297 kg of the phosphoric ester of the creatinol are obtained having these
characteristics: MP 240°C to 243°C.
| [Therapeutic Function]
Cardiotonic |
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