| Identification | More | [Name]
Flavin adenine dinucleotide disodium salt | [CAS]
84366-81-4 | [Synonyms]
FAD
FAD 2NA
FAD DISODIUM SALT
FAD-NA2
FLAVIN ADENINE DINUCLEOTIDE DISODIUM SALT
FLAVINE-ADENINE-DINUCLEOTIDE, DISODIUM
FLAVINE ADENINE DINUCLEOTIDE DISODIUM SALT
RIBOFLAVIN 5'-ADENOSINE DIPHOSPHATE DISODIUM SALT
FAD-Na2
riboflavin 5'-(trihydrogen diphosphate), 5'->5'-ester with adenosine, disodium salt
FLAVIN ADENINE DINUCLEOTIDE DISODIUM*CEL L CULTURE T
FLAVOXATE HYDROCHLORIDE (FAD)
Riboflavin 5-(trihydrogen diphosphate), P?5-ester with adenosine, disodium salt
Benzo[g]pteridine, riboflavin 5'-(trihydrogen diphosphate) deriv.
FAD sodium salt
flavin adenine dinucleotide sodium
Flavin adenine dinucleotide disodium salt hydrate, 94%(dry wt.), water <10%
Semiharden tallow fatty acid
FAD-Na2, FAD, Riboflavin 5μ-adenosine diphosphate disodium salt
Flavin adenine dinucleotide hydrate disodium salt | [EINECS(EC#)]
282-733-8 | [Molecular Formula]
C27H33N9Na2O16P2 | [MDL Number]
MFCD00151217 | [Molecular Weight]
847.53 | [MOL File]
84366-81-4.mol |
| Chemical Properties | Back Directory | [Appearance]
yellow-orange powder | [Melting point ]
>203°C (dec.) | [storage temp. ]
2-8°C
| [solubility ]
Methanol (Slightly, Heated), Water (Slightly) | [form ]
Powder | [color ]
yellow to orange-brown | [Water Solubility ]
5 g/L | [Merck ]
14,4091 | [BRN ]
5326842 | [Stability:]
Hygroscopic | [InChIKey]
PGEPWKYNISSNIQ-JQOOTDDSNA-N | [CAS DataBase Reference]
84366-81-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [Safety Statements ]
S24/25:Avoid contact with skin and eyes .
S22:Do not breathe dust . | [WGK Germany ]
3
| [RTECS ]
AU7470000 | [F ]
8-10-21 | [HS Code ]
29339900 |
| Hazard Information | Back Directory | [Description]
Flavin Adenine Dinucleotide Disodium Salt hydrate is an adenine-containing enzymatic redox cofactor. Also known as flavin cofactors and is critical electron transporter in living systems. FAD has been used as a predominant fluorophore to study unstained eosinophils, which exhibit autofluorescence compared to other leucocytes. | [Chemical Properties]
yellow-orange powder | [Uses]
The prosthetic group of certain flavoproteins including D-amino acid oxidase, glucose oxidase, glycine oxidase, fumaric hydrogenase, histaminase, and xanthine oxidase. Riboflavin kinase tumor necrosis factor receptor 1 NADPH oxidase. | [Definition]
ChEBI: Flavin adenine dinucleotide disodium is a flavin nucleotide. | [Biological Activity]
Flavin adenine dinucleotide (FAD) disodium salt is a redox cofactor, a prosthetic group of proteins, involved in several important enzymatic reactions during metabolism. | [in vitro]
Poly(Flavin adenine dinucleotide, FAD) characterized by an additional polymer-type redox reaction is a highly effective electrocatalyst for NADH oxidation: operating at the lowest potentials reported for NADH transducers (0.00 V, pH 7.4), poly(FAD) is characterized by the electrochemical rate constant of 1.8 ± 0.6×10 -3 cm/s, which is at the level of the NADH mass-transfer constant. Poly(FAD)-modified electrodes are characterized by the dramatically improved stability and, is the most advantageous NADH transducers for analytical chemistry. | [in vivo]
With Flavin adenine dinucleotide (2 mg/kg), the chlorpromazine (CPZ)-induced decrease in ventricular fibrillation threshold (VFT) is significantly cancelled. Flavin adenine dinucleotide cancels the effect of CPZ on canine heart mitochondria. After injection of Flavin adenine dinucleotide, the dogs show a transient hypotension within 10 min, then their blood pressures recover to the initial level. Flavin adenine dinucleotide also prevents mitochondrial dysfunction induced by chlorpromazine. | [Purification Methods]
Small quantities of FAD are purified by paper chromatography using tert-butyl alcohol/water, cutting out the main spot and eluting with water. Larger amounts can be precipitated from water as the uranyl complex by adding a slight excess of uranyl acetate to a solution at pH 6.0, dropwise and with gentle stirring. The solution is set aside overnight in the cold, and the precipitate is centrifuged off, washed with small portions of cold EtOH, then with cold peroxide-free diethyl ether. It is dried in the dark under vacuum over P2O5 at 50-60o. The uranyl complex is suspended in water, and, after adding sufficient 0.01M NaOH to adjust the pH to 7, the precipitate of uranyl hydroxide is removed by centrifugation [Huennekens & Felton Methods Enzymol 3 954 1957]. It can also be crystallised from water. It should be kept in the dark. More recently it was purified by elution from a DEAE-cellulose (Whatman DE 23) column with 0.1M phosphate buffer pH 7, and the purity was checked by TLC. [Holt & Cotton, J Am Chem Soc 109 1841 1987, Beilstein 26 III/IV 3632.] |
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