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980-71-2

980-71-2 Structure

980-71-2 Structure
IdentificationMore
[Name]

Brompheniramine hydrogen maleate
[CAS]

980-71-2
[Synonyms]

1-(n,n-dimethylamino)-3-(p-bromophenyl)-3-(alpha-pyridyl)propane maleate
1-p-bromophenyl-1-(2-pyridyl)-3-dimethylaminopropane maleate
BROMOPHENIRAMINE MALEATE
brompheniramine hydrogen maleate
BROMPHENIRAMINE MALEATE
(+/-)-BROMPHENIRAMINE MALEATE SALT
BROMPHENIRAMINE MALEATE SALT
2-(p-bromo-alpha-(2-(dimethylamino)ethyl)benzyl)pyridinemaleate(1:1)
2-(p-bromo-alpha-(2-(dimethylamino)ethyl)benzyl)-pyridinmaleate(1:1)
dimegan
dimetane
dimetanemaleate
dimotane
g-(4-bromophenyl)-N,N-dimethyl-2-pyridinepropanaminemaleate
gamma-(4-bromophenyl)-n,n-dimethyl-2-pyridinepropanamin(z)-2-butenedioate
gamma-(4-bromophenyl)-n,n-dimethyl-2-pyridinepropanamin(z)-butenedioate
ilvinmaleate
parabromdylaminemaleate
parabromodylaminemaleate
γ-(4-bromophenyl)-N,N-dimethyl-2-pyridinepropanaminemaleate
[EINECS(EC#)]

213-562-9
[Molecular Formula]

C20H23BrN2O4
[MDL Number]

MFCD00057367
[Molecular Weight]

435.31
[MOL File]

980-71-2.mol
Chemical PropertiesBack Directory
[Melting point ]

134-135°C
[Fp ]

9℃
[storage temp. ]

Inert atmosphere,Room Temperature
[solubility ]

Soluble in water, freely soluble in ethanol (96 per cent), in methanol and in methylene chloride.
[form ]

neat
[color ]

White to Off-White
[λmax]

261nm(lit.)
[Merck ]

14,1443
[Stability:]

Hygroscopic
[InChIKey]

SRGKFVAASLQVBO-BTJKTKAUSA-N
[LogP]

3.565 (est)
[CAS DataBase Reference]

980-71-2(CAS DataBase Reference)
[EPA Substance Registry System]

980-71-2(EPA Substance)
Safety DataBack Directory
[Hazard Codes ]

Xn,Xi
[Risk Statements ]

R22:Harmful if swallowed.
[Safety Statements ]

S36:Wear suitable protective clothing .
[RIDADR ]

3249
[WGK Germany ]

3
[RTECS ]

US4025000
[TSCA ]

Yes
[HazardClass ]

6.1(b)
[PackingGroup ]

III
[HS Code ]

38220090
Hazard InformationBack Directory
[Description]

Brompheniramine is a first generation antihistamine of the propylamine class. It antagonizes histamine H1 receptors (Ki = 6.06 nM) and also inhibits the reuptake of serotonin and norepinephrine.
[Chemical Properties]

White Solid
[Originator]

Dimetane,Robins,US,1957
[Uses]

Antihistaminic;H1 Antagonist
[Uses]

This drug is only available in combination with other medications: Bromfed, Dimetane, Dimetapp, Drixomed, Histatab, Nasahist. The only difference between this agent and chlorpheniramine is the substitution of a bromine for a chlorine atom in brompheniramine.
[Definition]

ChEBI: The maleic acid salt of brompheniramine. A histamine H1 receptor antagonist, it is used for the symptomatic relief of allergic conditions, including rhinitis and conjunctivitis.
[Manufacturing Process]

Initially, 4-bromobenzyl-cyanide is reacted with sodium amide and 2- chloropyridine to give bromophenyl-pyridyl acetonitrile. This is then reacted with sodium amide then dimethyl amino ethyl chloride to give 4-bromophenyldimethylaminoethyl- pyridyl acetonitrile. This intermediate is then hydrolyzed and decarboxylated to bromphenirame using 80% H2SO4 at 140°-150°C for 24 hours. The brompheniramine maleate may be made by reaction with maleic acid in ethanol followed by recrystallization from pentanol.
[Brand name]

Dimetane (Wyeth).
[Therapeutic Function]

Antihistaminic
[General Description]

Brompheniraminemaleate, (+)2-[p-bromo-α-[2-(dimethylamino)ethyl]benzyl]pyridine bimaleate (Dimetane), differs fromchlorpheniramine by the substitution of a bromine atom forthe chlorine atom. Its actions and uses are like those of chlorpheniramine.It has a half-life of 25 hours, which is almosttwice that of chlorpheniramine.
[Side effects]

The side effects of this medication are similar to other classes of sedative antihistamines. Some medications include parabens. Patients sensitive to parabens may develop a sensitivity reaction.
[storage]

Store at -20°C
Spectrum DetailBack Directory
[Spectrum Detail]

Brompheniramine hydrogen maleate(980-71-2)MS
Brompheniramine hydrogen maleate(980-71-2)IR1
Brompheniramine hydrogen maleate(980-71-2)IR2
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