100872-83-1
100872-83-1 结构式
基本信息
HSP70激动剂(ML346)
5-[3-(4-甲氧基苯基)-2-丙烯-1-基]-2,4,6(1H,3H,5H)-嘧啶三酮
CS-2056
ML346
ML 346
ML346 - CID 767276
2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-[3-(4-methoxyphenyl)-2-propen-1-ylidene]-
物理化学性质
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-18669 | ML346 ML346 | 100872-83-1 | 2mg | 600元 |
| 2024/04/30 | HY-18669 | ML346 ML346 | 100872-83-1 | 10mM * 1mLin DMSO | 898元 |
| 2024/04/30 | S6568 | ML346 ML346 | 100872-83-1 | 2mg | 1040.93元 |
常见问题列表
| Target | Value |
|
HSP70
() |
ML346 is an activator of Hsp70, with an EC 50 of 4600 nM in HeLa cells. ML346 (10 μM) restores proteostasis, restores CFTR-mediated iodide conductance, and enhances the correct folding of proteins expressed in two different cellular compartments. ML346 (Compound F1) induces multiple responses and strongly induces Hsp70, the oxidative stress response genes (HO1 and GCLM), and a 2.5-fold upregulation of BiP in WT MEF cells. ML346 (0.5-25 μM) exhibits cytoprotective effects in cells after a 35 min severe heat shock, and also causes a two-fold protection from H 2 O 2 -induced apoptosis.
ML346 suppress the aggregation of polyQ35 in a C. elegans model, suggesting the probe has efficacy in modifying protein aggregation and associated toxicity.