878978-76-8
878978-76-8 结构式
基本信息
中文别名
化合物ML-098GTP结合蛋白RAB7激活剂(ML-098)
英文别名
ML-809ML-098
CS-1456
CID7345532
CID 7345532
CID-7345532
ML098
ML 098
CID-7345532
CID 7345532
CID7345532
ML 098
ML098
1-[2-(2,5-dimethylphenoxy)ethyl]-1h-indole-3-carboxylic Acid
1H-Indole-3-carboxylic acid, 1-[2-(2,5-dimethylphenoxy)ethyl]-
所属类别
生物化工：激动剂抑制剂物理化学性质
沸点535.5±45.0 °C(Predicted)
密度1.17±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO:53.0(Max Conc. mg/mL);171.45(Max Conc. mM)
酸度系数(pKa)3.93±0.10(Predicted)
形态结晶固体
常见问题列表
生物活性
ML-098（CID-7345532）是GTP结合蛋白Rab7的激活剂，EC50值为77.6nM。靶点
EC50: 77.6 nM (Rab7)
体外研究
Probe compound mL098 (CID-7345532) functions by increasing the affinity of the GTPases for guanine nucleotides, leading to the hypothesis that these activators interact with GTPases bind to an allosteric binding site localized between switch regions I and II. ML-098 is an activator of the GTP-binding protein Rab7 with an EC 50 of 77.6 nM which shows selectivity against the related GTPases cdc42, Ras, Rab-2A, and Rac1 (EC50s = 588.8, 346.7, 158.5, and 794.3 nM, respectively).