134-47-4

中文名称猩红酸

英文名称 6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid)

CAS 134-47-4

EINECS 编号 205-142-9

分子式 C21H16N2O9S2

MDL 编号 MFCD00035715

分子量 504.49

MOL 文件 134-47-4.mol

更新日期 2023/03/20 15:41:21

134-47-4 结构式

基本信息物理化学性质安全数据应用领域上下游产品信息知名试剂公司产品信息猩红酸价格(试剂级) 常见问题列表

基本信息

中文别名

6,6'-(1,3-亚脲基)双(1,1'-萘酚)-3,3'-磺酸
猩红酸
7,7-(羰基二亚氨基)二(4-羟基-2-萘磺酸)

英文别名

4,4'-dihydroxy-7,7'-ureylenedi(naphthalene-2-sulphonic acid)
6,6'-ureylene-bis(1-naphthol-3-sulfonic acid)
7,7'-(Carbonyldiimino)bis[4-hydroxy-2-naphthalenesulfonic acid]
phosgenated
N,N'-bis(4-hydroxy-2-sulfonaphthalene-7-yl)urea
7,7'-Ureylenebis(4-hydroxy-2-naphthalenesulfonic acid)
N,N'-Bis[6-(1-naphthol-3-sulfonic acid)]urea
2-Naphthalenesulfonic acid, 7,7-(carbonyldiimino)bis4-hydroxy-
J ACID UREA, FREE ACID
66UREYLENEBIS1NAPHTHOL3SULPHONICACIDDISODIUMSALT
7,7'-(carbonyldiimino)bis[4-hydroxy-2-naphthalenesulfonic aci
6,6'-ureylenbis-1-naphthol-3-sulfonic acid
7,7'-(Carbonylbisimino)bis(4-hydroxynaphthalene-2-sulfonic acid)

所属类别

有机原料：羧酸的卤化、磺化、硝化或亚硝化衍生物

物理化学性质

密度1.798±0.06 g/cm3(Predicted)

储存条件Sealed in dry,Room Temperature

溶解度DMSO: 83.33 mg/mL (165.18 mM)

酸度系数(pKa)-0.17±0.40(Predicted)

CAS 数据库134-47-4(CAS DataBase Reference)

EPA化学物质信息7,7'-(Carbonyldiimino)bis[4-hydroxy-2-naphthalenesulfonic acid] (134-47-4)

安全数据

危险性符号(GHS)

GHS08

警示词警告

危险性描述H334

防范说明P261-P285-P304+P341-P342+P311-P403-P501c

应用领域

用途一

为偶氮染料用的中间体，用于制造直接橙S、直接耐酸大红4BS等

上下游产品信息

上游原料

亚硫酸氢钠焦亚硫酸钠

下游产品

直接红 23 直接橙 S 直接耐晒棕 8RLL 直接耐晒枣红 BL 直接红皮革黑直接耐晒枣红 BL 天狼猩红直接红 23

知名试剂公司产品信息

Sigma Aldrich

134-47-4(sigmaaldrich)

猩红酸价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2024/04/30	HY-18962A	猩红酸 AMI-1 free acid	134-47-4	5mg	187元
2024/04/30	HY-18962A	猩红酸 AMI-1 free acid	134-47-4	10mg	300元
2024/04/30	HY-18962A	猩红酸 AMI-1 free acid	134-47-4	10mM * 1mLin DMSO	330元

常见问题列表

生物活性

AMI-1 free acid 是一种有效的，细胞渗透性的，可逆的蛋白精氨酸 N-甲基转移酶 (PRMTs) 抑制剂，对人 PRMT1 和酵母 Hmt1p 作用的 IC50 值分别为 8.8 μM 和 3.0 μM。AMI-1 free acid 通过阻断肽-底物结合对 PRMTs 发挥抑制作用。

靶点

Target	Value
HMT ()
human PRMT1 ()
yeast Hmt1p (Cell-free assay)	3.0 μM

体外研究

AMI-1 free acid can inhibit the in vitro methylation reactions performed by all five recombinantly active PRMTs (PRMT1, -3, -4, and -6 and Hmt1p).
AMI-1 free acid not only inhibits type I PRMTs (PRMT1, 3, 4 and 6) but also type II PRMT5.
AMI-1 free acid specifically inhibits arginine, but not lysine, methyltransferase activity in vitro and does not compete for the AdoMet binding site.
AMI-1 free acid inhibits methylation of GFP-Npl3 and cellular proteins.
AMI-1 free acid (0.6-2.4 mM; 48-96 hours) inhibits the cell viability of sarcoma in S180 and U2OS cells in a time-dependent and dose-dependent manner in vitro.
AMI-1 free acid (1.2-2.4 mM; 48-72 hours) reduces S180 cell viability through the induction of cell apoptosis.

Cell Viability Assay

Cell Line:	S180 cells, U2OS cells
Concentration:	0.6 mM, 1.2 mM, 2.4 mM
Incubation Time:	48 hours, 72 hours, 96 hours
Result:	Inhibited the cell viability.

Apoptosis Analysis

Cell Line:	S180 cells
Concentration:	1.2 mM, 2.4 mM
Incubation Time:	48 hours, 72 hours
Result:	Increased the percentages of cells undergoing apoptosis.

体内研究

AMI-1 free acid (0.5 mg; intratumorally; daily; for 7 days) inhibits S180 viability in vivo.
AMI-1 free acid (0.5 mg; intratumorally; daily; for 7 days) downregulates PRMT5 but does not regulate the expression of PRMT7 in a tumor xenograft model.
AMI-1 free acid (0.5 mg; intratumorally; daily; for 7 days) decreases the levels of H4R3me2s and H3R8me2s in a tumor xenograft model.

Animal Model:	6-7 weeks old male Kunming mice (18-22 g), with S180 cells xenograft
Dosage:	0.5 mg
Administration:	Intratumorally, daily, for 7 days
Result:	Decreased tumor weight.