137361-05-8
中文名称
N-OMEGA-PROPYL-L-ARGININE
英文名称
N-OMEGA-PROPYL-L-ARGININE
CAS
137361-05-8
分子式
C9H20N4O2
MDL 编号
MFCD01320455
分子量
216.28
MOL 文件
137361-05-8.mol
137361-05-8 结构式
常见问题列表
生物活性
Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) 是一种高效、竞争性、高选择性的神经型一氧化氮合酶 (nNOS) 抑制剂，Ki为 57 nM。Nω-Propyl-L-arginine 对 nNOS 的选择性是内皮型一氧化氮合酶 (eNOS) 的 149 倍。体内研究
Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) (20 mg/kg; i.p.) blocks both phencyclidine-induced disruption of prepulse inhibition and phencyclidine-induced stimulation of locomotor activity.
| Animal Model: | Male NMRI mice (30-40 g) (phencyclidine-induced stimulation) |
| Dosage: | 20 mg/kg |
| Administration: | I.p. |
| Result: | Markedly reduced the phencyclidineinduced disruption of prepulse inhibition and significantly reduced the phencyclidine-induced stimulation of locomotor activity. |