3374-05-8
3374-05-8 结构式
基本信息
1-乙基-1,4-二氢-7-甲基-4-氧代-1,8-萘啶-3-羧酸钠盐
萘啶酮酸钠
NALIDIXIC ACID SODIUM SALT
1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylicacidsodium
8-naphthyridine-3-carboxylicacid,1-ethyl-1,4-dihydro-7-methyl-4-oxo-sodiu
nalidixatesodium
sodiumnalidixate
sodiumnilixalate
nalidixic acid sodium
nalidixic acid sodium gamma-irradiated*molecular
sodium 1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylate
NALIDIXIC ACID SODIUM GAMMA-IRRADIATED*M OLECULAR BI
NALIDIXIC ACID SODIUM SALT MOLECULAR BIOLOGY REAGENT
1,8-Naphthyridine-3-carboxylic acid, 1-ethyl-1,4-dihydro-7-methyl-4-oxo-, sodium salt
1,4-Dihydro-1-ethyl-4-oxo-7-methyl-1,8-naphthyridine-3-carboxylic acid sodium salt
1-Ethyl-4-oxo-7-methyl-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid sodium salt
物理化学性质
安全数据
常见问题列表
|
Topoisomerase
|
Nalidixic acid is against a variety of microorganisms, it is against with Escherichia coli , Pasteurella spp. , Klebsiella pneuiiioniae , Aerobacter aeroyenes , Proteus spp. , Salmonella spp. , Shigella spp. and Brucella spp. with MIC values of 5.0-12.5 μg/ml, 0.5-2.5 μg/ml, 0.8-25.0 μg/ml, 1.0-25.0 μg/ml, 1.25-30.0 μg/ml, 8-3.2 μg/ml, and 7.5-10.0 μg/ml, respectively.
The in vivo activity of Nalidixic acid is most pronounced against Gram-negative bacteria, while Gram-positive organisms are generally more resistant. Maximal activity is observed against systemic infections caused by E. coli , A. aerobacter , Proteus mirabilis , Shigella fkxneri , the ED 50 values are 25 mg/kg, 60 mg/kg, 50 mg/kg, and 62 mg/kg, respectively. The acute toxicity (LD 50 ) of Nalidixic acid in mice following oral and parenteral administration is: oral, 3300 mg/kg; intravenous, 176 mg/kg; and subcutaneous, 500 mg/kg.