3736-81-0
中文名称
糠酸二氯尼特
英文名称
Diloxanide furoate
CAS
3736-81-0
EINECS 编号
223-108-1
分子式
C14H11Cl2NO4
MDL 编号
MFCD00083302
分子量
328.15
MOL 文件
3736-81-0.mol
更新日期
2024/05/07 11:47:14
3736-81-0 结构式
基本信息
中文别名
糠二氯散糠酯酰胺
二氯尼特糠酸酯
三呋喃亞甲基二胺
三糠醛縮二胺
4-(N-甲基-2,2-二氯乙酰氨基)苯基 2-糠酸酯
糠酸二氯尼特
英文别名
2,2-DICHLORO-N-(4-HYDROXYPHENYL)-N-METHYLACETAMIDE 2-FUROIC ACID ESTERDILOXANIDE FUROATE
2-furancarboxylicacid,4-((dichloroacetyl)methylamino)phenylester
2-furoicacid,esterwith2,2-dichloro-4’-hydroxy-n-methylacetanilide
8073cb
amebiazol
dichlofurazol
diclofurazol
diloxanidfuroate
entamide2-furoate
entamidefuroate
furamide
furamide(amebicide)
furentomin
histomibal
4-[(dichloroacetyl)methylamino]phenyl 2-furoate
Diloxanide 2-furoic acid ester
所属类别
生物化工：激动剂抑制剂物理化学性质
熔点111-114 °C
沸点438.4±45.0 °C(Predicted)
密度1.424±0.06 g/cm3(Predicted)
储存条件2-8°C
溶解度可溶于氯仿（少许）、甲醇（少许）
酸度系数(pKa)-0?+-.0.50(Predicted)
形态固体
颜色灰白色至浅米色
BCS Class4
常见问题列表
生物活性
Diloxanide furoate 是二苯氧尼特的前药。Diloxanide furoate 是一种有效的具有口服活性的抗原虫制剂 (anti-protozoal agent)，可用于阿米巴病、轻度肠道阿米巴病或无症状包囊带菌感染的相关研究。体外研究
Diloxanide furoate (1.95-2.5 μg/ml) has potent activity against different strains of E. histolytica , it is against BYso (grown with bacteria), SFL3 (grown with Chrithidia sp.), and SFL3 (grown axenically) with MIC values of 2.5 μg/ml, 2.5 μg/ml and 1.95 μg/ml, respectively.
体内研究
Diloxanide furoate (oral administraion; 75-200 mg/kg; 3 days; once daily) is effective at different dose of dayin weanling rats. At 200 mg/kg, 100% of the treated rats are cured and no amoebic lesions are observed in the caecum. Besides, 85%,77%, and 44.4% of the treated rats are cured at the dose 150 mg/kg, 100 mg/kg, and 75 mg/kg, respectively. The ED 50 value is 77.9 mg/kg for this agent in rats.
| Animal Model: | Weanling Wistar rats |
| Dosage: | 200 mg/kg; 150 mg/kg; 100 mg/kg; 75 mg/kg |
| Administration: | Oral administraion; 75-200 mg/kg; 3 days; once daily |
| Result: | Was against intestinal (caecal) amoebiasis in rats. |