516-55-2
中文名称
别孕烯醇酮
英文名称
ALLOPREGNANOLONE
CAS
516-55-2
EINECS 编号
208-224-2
分子式
C21H34O2
MDL 编号
MFCD00064935
分子量
318.49
MOL 文件
516-55-2.mol
更新日期
2024/05/11 16:42:25
516-55-2 结构式
基本信息
中文别名
别孕烷醇酮异孕烷醇酮
别孕烯醇酮 别孕酮中间体
5ALPHA-孕甾-3BETA-醇-20-酮
5ALPHA-孕甾-3BETA-醇--20-酮,四氢孕酮非标
5ALPHA-孕甾-3BETA-醇-20-酮,四氢孕酮(17A,21,21,21-D4,97%+)96%PURE
1-[(8R,9S,10S,13S,14S,17S)-3-羟基-10,13-二甲基-2,3,4,5,6,7,8,9,11,12,14,15,16,17-十四氢-1H-环戊烷并[A]菲-17-基]乙酮
英文别名
ALLOPREGNANOLONE 所属类别
有机原料：酮类化合物物理化学性质
熔点200℃
比旋光度D27 +91.2° (c = 0.4 in ethanol)
沸点431.2±18.0 °C(Predicted)
密度1.1 g/cm3
储存条件Refrigerator
溶解度可溶于氯仿（少许）、甲醇（少许）
酸度系数(pKa)15.12±0.70(Predicted)
形态固体
颜色白色至灰白色
常见问题列表
用途
异丙孕酮用于制备抗菌和抗白血病类固醇。中间体。生物活性
Alloepipregnanolone 是一种具有催眠和镇静作用的孕酮，它能干扰乙醇抗焦虑作用的快速耐受。靶点
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Human Endogenous Metabolite
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体内研究
On day 2, pretreatment with a 0.20 mg/kg dose of Alloepipregnanolone blocks the development of rapid tolerance to the anxiolytic effect of ethanol. However, there is a significant decrease in the anxiolytic effect in the control groups that received ethanol on both days (EE), suggesting that the 1.5 g/kg dose of ethanol results in rapid tolerance. The post hoc analysis confirms that the 0.20 mg/kg pretreatment with Alloepipregnanolone blocks the rapid tolerance compared to the control groups, although the 0.10 mg/kg dose only partially blocks the development of such tolerance. However, the 0.05 mg/kg dose has no effect on the development of rapid tolerance to ethanol.