67776-06-1
中文名称
N-乙酰基-3-(硫代亚硝基)-DL-缬氨酸
英文名称
2-acetamido-3-methyl-3-(nitrososulfanyl)butanoic acid
CAS
67776-06-1
分子式
C7H12N2O4S
MDL 编号
MFCD00272624
分子量
220.25
MOL 文件
67776-06-1.mol
更新日期
2024/04/12 16:33:24
67776-06-1 结构式
基本信息
中文别名
S-亚硝基-N-乙酰-DL-青霉胺S-亚硝基N-乙酰基-DL-青霉胺
N-乙酰基-3-(亚硝基硫代)-缬氨酸
N-乙酰基-3-(硫代亚硝基)-DL-缬氨酸
S-亚硝基-N-乙酰基-DL-青霉胺(SNAP)
英文别名
SNAP 所属类别
生物化工：缬氨酸类衍生物物理化学性质
熔点150.5°C
密度1.4261 (rough estimate)
RTECS号YV9383000
折射率1.5400 (estimate)
储存条件−20°C
溶解度H2O: ≥2 mg/mL
酸度系数(pKa)3.06±0.10(Predicted)
形态powder
形态粉末
颜色green
颜色绿色
常见问题列表
生物活性
S-Nitroso-N-acetyl-DL-penicillamine (SNAP) 是一种一氧化氮供体，是一种稳定的血小板聚集抑制剂。体外研究
S-Nitroso-N-acetyl-DL-penicillamine (10 mM; 8 hours) induces toxicity of about 80% after 6 hours under normoxic conditions by releasing nitric oxide (NO).
S-Nitroso-N-acetyl-DL-penicillamine has a half-time about 6 hours in in isolated rat ventricular myocytes.
S-Nitroso-N-acetyl-DL-penicillamine (100 µM; 30 minutes) causes sustained decrease in the basal pHi in isolated rat ventricular myocytes.
Cell Viability Assay
| Cell Line: | Rat liver sinusoidal endothelial cells |
| Concentration: | 2 mM, 5 mM, 10 mM |
| Incubation Time: | 2 hours, 4 hours, 6 hours, 8 hours |
| Result: | Exhibited cytotoxicity against cultivated endothelial cells. |
体内研究
SNAP (100μM, 300μM) causes small but significant increases of the electrically evoked [
3
H]-acetylcholine release in guinea-pig tracheal.