氟辛克生
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- CAS号:
- 98206-10-1
- 英文名:
- Flesinoxan
- 英文别名:
- FLESINOXAN;N-[2-[4-[[(S)-2,3-Dihydro-2β-hydroxymethyl-1,4-benzodioxin]-5-yl]-1-piperazinyl]ethyl]-4-fluorobenzamide;N-[2-[4-[[(R)-2,3-Dihydro-2α-hydroxymethyl-1,4-benzodioxin]-5-yl]-1-piperazinyl]ethyl]-4-fluorobenzamide;N-(2-(4-((2R)-2,3-Dihydro-2-(hydroxymethyl)-1,4-benzodioxin-5-yl)-1-piperazinyl)ethyl)-4-fluorobenzamide;Benzamide, N-[2-[4-[(2R)-2,3-dihydro-2-(hydroxymethyl)-1,4-benzodioxin-5-yl]-1-piperazinyl]ethyl]-4-fluoro-
- 中文名:
- 氟辛克生
- 中文别名:
- 氟辛克生;化合物 T16711;N-(2-(4-((2R)-2,3-二氢-2-(羟甲基)-1,4-苯并二恶英-5-基)-1-哌嗪基)乙基)-4-氟苯甲酰胺
- CBNumber:
- CB0295444
- 分子式:
- C22H26FN3O4
- 分子量:
- 415.46
- MOL File:
- 98206-10-1.mol
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氟辛克生化学性质
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比旋光度:
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D +26° (c = 1 in methanol)
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沸点:
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635.8±55.0 °C(Predicted)
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密度:
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1.271±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 31.25 mg/mL (75.22 mM)
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酸度系数(pKa):
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14.09±0.10(Predicted)
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氟辛克生性质、用途与生产工艺
Flesinoxan 是一种降压剂,是一种有效的,高亲和力的选择性的 5-羟色胺 1A (5-HT1A) 受体激动剂,EC50 值为 24 nM。Flesinoxan 还具有有效的抗焦虑/抗抑郁作用。
5-HT
1A
Receptor
24 nM (EC
50
)
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Flesinoxan acts as a partial agonist at postsynaptic and as a full agonist at presynaptic 5-HT1A receptors. The capacity of Flesinoxan to antagonize the effect of 5-HT on CA3 pyramidal neurons was similar to that of 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT).
The intravenous administration of Flesinoxan suppresses the firing activity of both CA3 pyramidal neurons and dorsal raphe 5-HT neurons. The acute brain penetration of [
3
H]Flesinoxan and [
3
H]8-OH-DPAT are determined. Nine minutes after intravenous administration, [
3
H]8-OH-DPAT reached significantly greater brain concentration than [
3
H]Flesinoxan.
Subcutaneous administration of Flesinoxan and 8-OH-DPAT produce a dose-dependent hypothermia. The Flesinoxan-induced hypothermia is significantly attenuated by prior administration of the non-selective 5-HT1A antagonist pindolol and the 5-HT1/2 antagonist methysergide. Similar degrees of hypothermia are achieved with 3 mg/kg of Flesinoxan and 0.5 mg/kg of 8-OH-DPAT. The maximal effect of Flesinoxan occurs 30 min later than that of 8-OH-DPAT and fades more slowly.
氟辛克生
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下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-121653 | 氟辛克生 Flesinoxan | 98206-10-1 | 5mg | 4500元 |
2024/04/30 | HY-121653 | 氟辛克生 Flesinoxan | 98206-10-1 | 10mM * 1mLin DMSO | 4950元 |
98206-10-1, 氟辛克生 相关搜索:
- C22H26FN3O4
- 化合物 T16711
- 氟辛克生
- N-(2-(4-((2R)-2,3-二氢-2-(羟甲基)-1,4-苯并二恶英-5-基)-1-哌嗪基)乙基)-4-氟苯甲酰胺
- 98206-10-1
- Benzamide, N-[2-[4-[(2R)-2,3-dihydro-2-(hydroxymethyl)-1,4-benzodioxin-5-yl]-1-piperazinyl]ethyl]-4-fluoro-
- N-(2-(4-((2R)-2,3-Dihydro-2-(hydroxymethyl)-1,4-benzodioxin-5-yl)-1-piperazinyl)ethyl)-4-fluorobenzamide
- FLESINOXAN
- N-[2-[4-[[(S)-2,3-Dihydro-2β-hydroxymethyl-1,4-benzodioxin]-5-yl]-1-piperazinyl]ethyl]-4-fluorobenzamide
- N-[2-[4-[[(R)-2,3-Dihydro-2α-hydroxymethyl-1,4-benzodioxin]-5-yl]-1-piperazinyl]ethyl]-4-fluorobenzamide