CARBACYCLIN
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- CAS号:
- 69552-46-1
- 英文名:
- CARBACYCLIN
- 英文别名:
- CPGI;Carba pgx;Carba-PGI2;CARBACYCLIN;Carbacycline;6A-Carba-pgi2;6,9-Methano-pgi2;6,9-Methano pgi2;CARBACYCLIC PGI2;CARBOCYCLIC PGI2
- 中文名:
- CARBACYCLIN
- 中文别名:
- 卡巴环素;化合物 T10673
- CBNumber:
- CB0475042
- 分子式:
- C21H34O4
- 分子量:
- 350.49
- MOL File:
- 69552-46-1.mol
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CARBACYCLIN化学性质
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熔点:
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65-67℃
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沸点:
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514.8±50.0 °C(Predicted)
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密度:
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1.177±0.06 g/cm3(Predicted)
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储存条件:
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−20°C
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溶解度:
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Soluble at 20mg/ml in ethanol.
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形态:
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Solid
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酸度系数(pKa):
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4.77±0.10(Predicted)
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CARBACYCLIN性质、用途与生产工艺
Carbacyclin 是 PGI2 的类似物，为前列腺环素 (prostacyclin (PGI2)) 受体激动剂和血管舒张剂，能够有效抑制血小板聚集；Carbacyclin 同时可以通过 PPARδ 来诱导 CPT-1 mRNA 的表达，不依赖 IP 受体信号通路。
Carbacyclin is an agonist of prostacyclin (PGI2) receptor. Carbacyclin acts as an inhibitor of platelet aggregation induced by ADP or collagen in vitro. Carbacyclin is a PGI2 analogue, activates CPT-1 mRNA expression through PPARδ, independent of the IP receptor signaling pathway. Carbacyclin (0.02 μM to 20 μM) activates the IP receptor signaling pathway via PKA, and such an effect is inhibited by H-89, a PKA inhibitor. Carbacyclin (0.02-80 μM) increases PPRE promoter activity via PPARδ independent of the IP receptor signaling pathway in cardiomyocytes.
Carbacyclin is 0.03 times as active as prostacyclin on inhibiting platelet aggregation in human, dog or rabbit plasma. Carbacyclin (100 μg, i.p.) induces CPT-1 mRNA expression in murine heart.
CARBACYCLIN
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-112322 | CARBACYCLIN
Carbacyclin | 69552-46-1 | 1mg | 6200元 |
69552-46-1, CARBACYCLIN 相关搜索:
- Fatty Acids
- Lipids
- Prostaglandins
- Biochemicals and Reagents
- BioChemical
- 化合物 T10673
- 卡巴环素
- 69552-46-1
- Carbacyclin (Carbocyclic PGI?)
- Carba-PGI2
- Pentanoic acid,5-[(3aS,4R,5R,6aS)-hexahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-1-octenyl]-2(1H)-pentalenylidene]-,(5E)-
- CPGI
- CARBOCYCLIC PGL2
- CARBOCYCLIC PGI2
- CARBAPROSTACYCLIN
- CARBACYCLIN
- CARBACYCLIC PGI2
- Carbacyclin (Carbocyclic PGI2)
- Carbacycline
- Carba pgx
- 9alpha-Deoxy-9alpha-methylene-pgi2
- 6A-Carba-pgi2
- 6,9-Methano-pgi2
- 6,9-Methano pgi2
- (5E)-6A-Carba-prostaglandin I2
- 5-[(2E,3aS,5R,6aβ)-Octahydro-5α-hydroxy-4β-[(1E,3S)-3-hydroxy-1-octenyl]pentalen-2-ylidene]pentanoic acid
- 5-[(1β,3E,5β,6R)-6β-[(1E,3S)-3-Hydroxy-1-octenyl]-7α-hydroxybicyclo[3.3.0]octane-3-ylidene]pentanoic acid
- (5E)-6a-Carbaprostaglandin 12
- 6a-Carba-prostaglandinI2, CarbocyclicPGI2
- 6,9-Methanoprostaglandin I2
- carboprostacyclin
- 6A-CARBA-PROSTAGLANDIN I2
- 6,9ALPHA-METHYLENE-11ALPHA,15S-DIHYDROXY-PROSTA-5E,13E-DIEN-1-OIC ACID