达舒平
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- CAS号:
- 3737-09-5
- 英文名:
- DISOPYRAMIDE
- 英文别名:
- h3292;sc7031;H 3292;H. 3292;Lispine;SC 7031;Isorythm;Ritmodan;Ritmilen;searle703
- 中文名:
- 达舒平
- 中文别名:
- 达舒平;丙吡胺;异脉定;双异丙吡胺;达舒平 溶液;丙吡胺 标准品;达舒平 标准品;丙吡胺 EP标准品;DISOPYRAMIDE[干冰运输];4-二异丙氨基-2-苯基-2-(2-吡啶基)丁酰胺
- CBNumber:
- CB1285468
- 分子式:
- C21H29N3O
- 分子量:
- 339.48
- MOL File:
- 3737-09-5.mol
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达舒平化学性质
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熔点:
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94.5-950C
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沸点:
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475.43°C (rough estimate)
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密度:
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1.0779 (rough estimate)
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折射率:
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1.6300 (estimate)
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储存条件:
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Inert atmosphere,Room Temperature
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溶解度:
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Soluble in DMSO (25 mg/ml) and Ethanol (>35 mg/mL)
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形态:
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solid
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酸度系数(pKa):
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10.2; also reported as 10.45(at 25℃)
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颜色:
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White
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水溶解性:
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6.17mg/L(22.5 ºC)
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Merck:
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14,3360
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稳定性:
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Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
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CAS 数据库:
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3737-09-5(CAS DataBase Reference)
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达舒平性质、用途与生产工艺
Disopyramide (Dicorantil) 是一种用于研究室性和房性心律失常的 IA 类抗心律失常试剂。Disopyramide 阻断心肌快速内向钠电流 (sodium current)，延长心肌动作电位持续时间。Disopyramide 抑制 HERG 编码的钾通道 (potassium channels)。Disopyramide 也表现出复杂的蛋白质结合，并具有强大的负性肌力作用。
HERG tail currents recorded at -40 mV following test pulses to +30 mV were inhibited in a dose-dependent fashion by Disopyramide concentrations within the clinical range (IC
50
=7.23 μM).
用途
心脏病类药。抗心律失常，适用于室上性室心早搏、各类心动过速房颤等。
生产方法
2-溴吡啶与苄腈、N,N-二异丙基氯乙胺缩合、水解，再与磷酸成盐即得到治疗心律失常药双异丙吡胺。
达舒平
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-12533 | Disopyramide | | 5 mg | 250元 |
| 2024/04/30 | D2793 | 丙吡胺
Disopyramide | 3737-09-5 | 1g | 390元 |
达舒平
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达舒平国内生产厂家
3737-09-5, 达舒平 相关搜索:
- Pharmaceuticals
- Intermediates & Fine Chemicals
- 药靶配体
- 合成有机化合物配体
- 医药原料药
- 合成
- 小分子抑制剂
- Ion Channels
- Other Sodium Channel Modulators
- Monovalent Ion Channels
- BioChemical
- Cell Biology
- Cell Signaling and Neuroscience
- Voltage-gated Ion Channels
- Sodium Channel Modulators
- C21H28N3O
- C21H29N3O
- 9/5/3737
- 4-(二异丙基氨基)-2-苯基-2-(2-吡啶基)丁酰胺
- 4-二异丙氨基-2-苯基-2-(2-吡啶基)丁酰胺
- DISOPYRAMIDE[干冰运输]
- 达舒平 标准品
- 丙吡胺 EP标准品
- 丙吡胺 标准品
- 异脉定
- 双异丙吡胺
- 达舒平
- 丙吡胺
- 达舒平 溶液
- 3737-09-5
- 4-(Diisopropylamino)-2-phenyl-2-(2-pyridyl)butanamide
- arrhythmias,SC7031,Inhibitor,inhibit,Potassium Channel,negative,Na channels,Disopyramide,SC-7031,Sodium Channel,ventricular,SC 7031,Na+ channels,antiarrhythmic,inotropic,Dicorantil,action,atrial,KcsA
- DisopyramideQ: What is
Disopyramide Q: What is the CAS Number of
Disopyramide Q: What is the storage condition of
Disopyramide Q: What are the applications of
Disopyramide
- DISOPYRAMIDE USP/EP/BP
- isopyramide
- Disopyramide >
- Disopyramide CRS
- (RS)-disopyramide
- Ritmilen
- dl-Disopyramide
- a-[2-[Bis(1-methylethyl)amino]ethyl]-a-phenyl- 2-pyridineacetamide
- a-[2-(Diisopropylamino)ethyl]-a-phenyl-2-pyridineacetamide
- SC 7031
- Ritmodan
- Lispine
- Isorythm
- h3292
- H. 3292
- H 3292
- gamma-Diisopropylamino-alpha-phenyl-alpha-(2-pyridyl)butyramide
- Dicorantil
- alpha-(2-(diisopropylamino)ethyl)-alpha-phenyl-2-pyridineacetamid
- 4-Diisopropylamino-2-phenyl-2-(2-pyridyl)-butyramide
- 4-(Diisopropylamino)-2-phenyl-2-(2-pyridinyl)butanamide
- 2-Pyridineacetamide, alpha-[2-[bis(1-methylethyl)amino]ethyl]-alpha-phenyl-
- 2-Pyridineacetamide, alpha-[2-(diisopropylamino)ethyl]-alpha-phenyl-
- ALPHA-DIISOPROPYLAMINOETHYL-ALPHA-PHENYLPYRIDINE-2-ACETAMIDE
- ALPHA-[2-[BIS(1-METHYLETHYL)AMINO]ETHYL]-ALPHA-PHENYL-2-PYRIDINE ACETAMIDE