泛托法隆
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- CAS号:
- 114432-13-2
- 英文名:
- Fantofarone
- 英文别名:
- CS-2766;SR-33557;Fantofarone;FANTOFARONE;SR-33557;SR33557; 114432-13-2;Parasite,Fantofarone,Ca channels,Calcium Channel,inhibit,SR33557,SR-33557,Inhibitor,Ca2+ channels;2-Isopropyl-1-[[4-[3-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]propoxy]phenyl]sulfonyl]indolizine;3,4-Dimethoxy-N-methyl-N-[3-[4-[[2-(1-methylethyl)-1-indolizinyl]sulfonyl]phenoxy]propyl]benzeneethanamine;Benzeneethanamine, 3,4-dimethoxy-N-methyl-N-[3-[4-[[2-(1-methylethyl)-1-indolizinyl]sulfonyl]phenoxy]propyl]-
- 中文名:
- 泛托法隆
- 中文别名:
- 泛托法隆;芬托法隆;3,4-二甲氧基-N-甲基-N- [3-[4-[[2-(1-甲基乙基)-1-氮茚基]磺酰基]苯氧基]丙基]苯乙胺
- CBNumber:
- CB21118032
- 分子式:
- C31H38N2O5S
- 分子量:
- 550.71
- MOL File:
- 114432-13-2.mol
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泛托法隆化学性质
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熔点:
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82-83°
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密度:
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dz 1.21 g/cm3
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储存条件:
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Store at -20°C
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溶解度:
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DMF: 10 mg/ml; DMSO: 10 mg/ml
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形态:
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A crystalline solid
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酸度系数(pKa):
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8.34 ± 0.05(at 25℃)
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泛托法隆性质、用途与生产工艺
Fantofarone 是钙离子通道 (Calcium Channel) 的强效拮抗剂。
It can be seen that the calcium channel blockers VIZ and Fantofarone (SR) possess a weak intrinsic antimalarial property compared to CQ, and both appear slightly more potent on the CQ-resistant than on the CQ-sensitive parasites. Interestingly, Fantofarone is
ca
. 10 times more potent than verapamil. Fantofarone (SR) is 10 times more potent than the phenylalkylamine verapamil (VR) on the two
P. fdciparum
strains. As revealed by the isobolograms, the two calcium channel blockers potentiate the CQ sensitivity activity on the CQ-resistant
P. fufcipurum
strain, verapamil appearing 2 to 3 times more potent than Fantofarone. Furthermore, when used at similar subinhibitory fractions of their IC
50
, VR is 2 to 3 times more potent than Fantofarone in decreasing CQ resistance.
Treatment with isosorbide dinitrate (0.3 mg/kg, i.v.) or Fantofarone (50 mg/kg, i.v.), a reduction is observed in the occurrence and severity of vasospasm, whereas verapamil (0.2 mg/kg, i.v.) is much less effective. Although it totally inhibits distal AIV, isosorbide dinitrate does not significantly affect proximal diameter decrease. The most potent compound with regard to both the distal and proximal vasospasms is Fantofarone, which significantly reduces AIV throughout the experiment. Verapamil does not reduce AIV significantly.
泛托法隆
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-105117 | Fantofarone | | 1 mg | 400元 |
| 2024/04/30 | HY-105117 | 泛托法隆
Fantofarone | 114432-13-2 | 5mg | 900元 |
114432-13-2, 泛托法隆 相关搜索:
- API
- 药靶配体
- C31H38N2O5S
- 芬托法隆
- 3,4-二甲氧基-N-甲基-N- [3-[4-[[2-(1-甲基乙基)-1-氮茚基]磺酰基]苯氧基]丙基]苯乙胺
- 泛托法隆
- 114432-13-2
- Parasite,Fantofarone,Ca channels,Calcium Channel,inhibit,SR33557,SR-33557,Inhibitor,Ca2+ channels
- Benzeneethanamine, 3,4-dimethoxy-N-methyl-N-[3-[4-[[2-(1-methylethyl)-1-indolizinyl]sulfonyl]phenoxy]propyl]-
- CS-2766
- FANTOFARONE;SR-33557;SR33557; 114432-13-2
- 3,4-Dimethoxy-N-methyl-N-[3-[4-[[2-(1-methylethyl)-1-indolizinyl]sulfonyl]phenoxy]propyl]benzeneethanamine
- SR-33557
- 2-Isopropyl-1-[[4-[3-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]propoxy]phenyl]sulfonyl]indolizine
- Fantofarone