N,N'-八亚甲基双二氯乙酰胺
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- CAS号:
- 1477-57-2
- 英文名:
- N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)
- 英文别名:
- SKL878;r-010-tk;win18441;win18446;win18,446;NSC 59354;bisdiamine;FERTILYSIN;bis-diamine;Fertilysine
- 中文名:
- N,N'-八亚甲基双二氯乙酰胺
- 中文别名:
- 佛替来辛;N,N'-八亚甲基双二氯乙酰胺;N,N′-八亚甲基双(2,2-二氯乙酰胺);N,N′-双(二氯乙酰基)-1,8-八亚甲基二胺;N,N'-1,8-辛二基双[2,2-二氯]乙酰胺;N,N'-(辛烷-1,8-二基)双(2,2-二氯乙酰胺);N,N'-(辛烷-1,8-二基)双(2,2-二氯乙酰胺)
- CBNumber:
- CB2146249
- 分子式:
- C12H20Cl4N2O2
- 分子量:
- 366.11
- MOL File:
- 1477-57-2.mol
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N,N'-八亚甲基双二氯乙酰胺化学性质
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熔点:
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118-120 °C
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沸点:
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530℃
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密度:
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0.726
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折射率:
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1.6200 (estimate)
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闪点:
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275℃
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储存条件:
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Inert atmosphere,2-8°C
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溶解度:
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Acetone (Very Slightly), DMSO (Slightly), Methanol (Sparingly, Heated, Sonicated
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酸度系数(pKa):
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12.28±0.46(Predicted)
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形态:
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Solid
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颜色:
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White to Off-White
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CAS 数据库:
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1477-57-2
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N,N'-八亚甲基双二氯乙酰胺性质、用途与生产工艺
Win 18446 是具有口服活性的睾丸特异性的酶 ALDH1a2 的抑制剂，其 IC50 值为 0.3 μM。Win 18446 可逆的抑制多个物种的精子形成，抑制睾丸内视黄醇 (HY-B1342) 合成视黄酸 (HY-14649)。
WIN 18446 (1 μM, 24 h) is able to suppress Stra8 expression in whole-testes cultures that contained both germ and somatic cells.
RT-PCR
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Cell Line:
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Testes were collected from 2-dpp mice.
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Concentration:
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1 μM.
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Incubation Time:
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24 h.
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Result:
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Results in a VAD-like phenotype in the testis.
Alone or in combination with ROL significantly reduced
Stra8
expression.
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Win 18446 (200 mg/kg, Orally for 4, 8, and 16 weeks) significantly reduces intratesticular concentrations of retinoic acid, severely impaired spermatogenesis, and caused infertility.
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Animal Model:
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Six-month-old male New Zealand white rabbits.
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Dosage:
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200 mg/kg.
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Administration:
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Orally for 4, 8, and 16 weeks.
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Result:
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Resulted in marked suppression of testicular weight over time.
Dramatically suppressed spermatogenesis.
Significantly reduces intratesticular concentrations of retinoic acid and Stra8 expression and very severely suppresses spermatogenesis and fertility.
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类别
有毒物品
毒性分级
高毒
急性毒性
腹腔-小鼠 LDL0: 150 毫克/公斤
可燃性危险特性
可燃; 受热产生有毒氮氧化物,氯化物烟雾; 药物副作用:恶心,呕吐,精子形成改变
储运特性
库房通风低温干燥; 与食品原料分开存放
灭火剂
干粉,泡沫,沙土,二氧化碳, 雾状水
N,N'-八亚甲基双二氯乙酰胺
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-W011094 | N,N'-八亚甲基双二氯乙酰胺
Win 18446 | 1477-57-2 | 50mg | 973元 |
| 2024/04/30 | HY-W011094 | N,N'-八亚甲基双二氯乙酰胺
Win 18446 | 1477-57-2 | 10mM * 1mLin DMSO | 1100元 |
1477-57-2, N,N'-八亚甲基双二氯乙酰胺 相关搜索:
- 有机中间体
- 其它
- C12H20Cl4N2O2
- N,N'-(辛烷-1,8-二基)双(2,2-二氯乙酰胺)
- N,N'-(辛烷-1,8-二基)双(2,2-二氯乙酰胺)
- N,N'-八亚甲基双二氯乙酰胺
- 佛替来辛
- N,N′-双(二氯乙酰基)-1,8-八亚甲基二胺
- N,N′-八亚甲基双(2,2-二氯乙酰胺)
- N,N'-1,8-辛二基双[2,2-二氯]乙酰胺
- 1477-57-2
- N,N'-(Octane-1,8-diyl)bis(2,2-dichloroacetamide)
- 2,2-dichloro-N-[8-[(2,2-dichloroacetyl)amino]octyl]acetamide
- WIN 18446,Stra8,testis,spermatogenesis,inhibit,Win18446,Aldehyde Dehydrogenase (ALDH),Testes,Win-18446,Inhibitor
- SKL878
- Fertilysine
- AcetaMide,N,N'-1,8-octanediylbis[2,2-dichloro-
- N,N'-(Octane-1,8-diyl)bis(2,2-dichloroacetaMide)
- N,N'-Octamethylenebis(dichloroacetamide),97%
- N,N'-(1,8-Octanediyl)bis(2,2-dichloroacetamide)
- N,N''-OCTMETHYLENEBIS (DICHLOROACETAMIDE)
- NSC 59354
- win18446
- win18441
- win18,446
- r-010-tk
- n,n-bis(dichloroacetyl)-1,8-octanediamine
- n,n’-octamethylenebis(2,2-dichloroactamide)
- n,n’-octamethylenebis(2,2-dichloro-acetamid
- n,n’-bis(dichloroacetyl)-1,8-octanediamine
- n,n’-bis(dichloroacetyl)-1,8-diaminooctane
- n,n’,1,8-octanediylbis(2,2-dichloro-acetamid
- bis-diamine
- bisdiamine
- N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)
- N,N'-OCTA-METHYLENE-BIS[2,2-DICHLOROACETAMIDE]
- N,N'-BIS(DICHLOROACETYL)-1,8-OCTAMETHYLENEDIAMINE
- FERTILYSIN