792957-74-5
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- CAS号:
- 792957-74-5
- 英文名:
- ER-000444793
- 英文别名:
- ER-000444793;ER-000444793
(ER000444793);N-(2-Benzylphenyl)-2-oxo-1,2-dihydroquinoline-4-carboxamide;4-Quinolinecarboxamide, 1,2-dihydro-2-oxo-N-[2-(phenylmethyl)phenyl]-;Mitochondrial Metabolism,Inhibitor,ER-000444793,inhibit,ER000444793,ER 000444793
- 中文名:
- 792957-74-5
- 中文别名:
- 化合物ER-000444793;N-(2-苄基苯基)-2-氧代-1,2-二氢喹啉-4-甲酰胺
- CBNumber:
- CB23155149
- 分子式:
- C23H18N2O2
- 分子量:
- 354.4
- MOL File:
- 792957-74-5.mol
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792957-74-5化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : ≥ 100 mg/mL (282.17 mM)
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792957-74-5性质、用途与生产工艺
ER-000444793 是有效的线粒体通透性转换孔 (mPTP) 开放抑制剂。ER-000444793 抑制 mPTP， IC50 为 2.8 μM。
ER-000444793 is a small molecule, non-toxic mPTP inhibitor with a mechanism of action independent of CypD inhibition. ER-000444793 potently and dose-dependently inhibits Ca
2+
-induced mPT. ER-000444793 binds CypD, a CsA/CypD homogenous time-resolved fluorescence (HTRF) assay is used to study compound binding. Both CsA and SfA dose-dependently decrease HTRF signal, suggesting displacement of labelled CsA from rhCypD protein (CsA IC
50
=23 nM and SfA IC
50
= 5 nM). In contrast, ER-000444793 has no effect up to a concentration of 50 μM, indicating lack of displacement of labelled-CsA from rhCypD protein. Together, these data suggest the mechanism of ER-000444793 in delaying mPT is independent of CypD functional inhibition.
792957-74-5
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-100852 | 792957-74-5
ER-000444793 | 792957-74-5 | 1mg | 880元 |
| 2024/01/25 | HY-100852 | 792957-74-5
ER-000444793 | 792957-74-5 | 5mg | 2000元 |
792957-74-5, 792957-74-5 相关搜索:
- 药靶配体
- N-(2-苄基苯基)-2-氧代-1,2-二氢喹啉-4-甲酰胺
- 化合物ER-000444793
- 792957-74-5
- Mitochondrial Metabolism,Inhibitor,ER-000444793,inhibit,ER000444793,ER 000444793
- N-(2-Benzylphenyl)-2-oxo-1,2-dihydroquinoline-4-carboxamide
- 4-Quinolinecarboxamide, 1,2-dihydro-2-oxo-N-[2-(phenylmethyl)phenyl]-
- ER-000444793
(ER000444793)
- ER-000444793