792957-74-5
| 中文名称 | 792957-74-5 |
|---|---|
| 中文同义词 | 化合物ER-000444793;N-(2-苄基苯基)-2-氧代-1,2-二氢喹啉-4-甲酰胺 |
| 英文名称 | ER-000444793 |
| 英文同义词 | ER-000444793;ER-000444793 (ER000444793);4-Quinolinecarboxamide, 1,2-dihydro-2-oxo-N-[2-(phenylmethyl)phenyl]-;N-(2-Benzylphenyl)-2-oxo-1,2-dihydroquinoline-4-carboxamide;Mitochondrial Metabolism,Inhibitor,ER-000444793,inhibit,ER000444793,ER 000444793 |
| CAS号 | 792957-74-5 |
| 分子式 | C23H18N2O2 |
| 分子量 | 354.4 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 792957-74-5.mol |
| 结构式 |  |
792957-74-5 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 二甲基亚砜：≥100mg/mL（282.17mM） |
IC50: 2.8 μM (mPTP)
ER-000444793 is a small molecule, non-toxic mPTP inhibitor with a mechanism of action independent of CypD inhibition. ER-000444793 potently and dose-dependently inhibits Ca 2+ -induced mPT. ER-000444793 binds CypD, a CsA/CypD homogenous time-resolved fluorescence (HTRF) assay is used to study compound binding. Both CsA and SfA dose-dependently decrease HTRF signal, suggesting displacement of labelled CsA from rhCypD protein (CsA IC 50 =23 nM and SfA IC 50 = 5 nM). In contrast, ER-000444793 has no effect up to a concentration of 50 μM, indicating lack of displacement of labelled-CsA from rhCypD protein. Together, these data suggest the mechanism of ER-000444793 in delaying mPT is independent of CypD functional inhibition.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-100852 | 792957-74-5 ER-000444793 | 792957-74-5 | 1mg | 880元 |
| 2024/04/30 | HY-100852 | 792957-74-5 ER-000444793 | 792957-74-5 | 5mg | 2000元 |