硫前列酮
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- CAS号:
- 60325-46-4
- 英文名:
- Sulprostone
- 英文别名:
- sch286;SHB-286;Nalador;ZK-57671;CP-34089;CP-34086;SULPROSTONE;Sulprostone USP/EP/BP;Sulprostone >=95% (HPLC), oil;Sulprostone in 5mg/ml Methyl Acetate
- 中文名:
- 硫前列酮
- 中文别名:
- 硫前列酮;舒普洛司通;素普罗斯顿;化合物 T23404;硫前列酮/SULPROSTONE;(Z)-7-[(1R,2R,3R)-3-羟基-2-((E,3R)-3-羟基-4-苯氧基-1-丁烯基)-5-氧代环戊基]-N-甲基磺酰基-5-庚烯酰胺
- CBNumber:
- CB3224098
- 分子式:
- C23H31NO7S
- 分子量:
- 465.56
- MOL File:
- 60325-46-4.mol
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硫前列酮化学性质
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熔点:
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79.25°C
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密度:
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1.1918 (rough estimate)
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折射率:
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1.5650 (estimate)
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储存条件:
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-20°C
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溶解度:
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DMSO: >5 mg/mL
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酸度系数(pKa):
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4.63±0.40(Predicted)
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形态:
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solid
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颜色:
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white to off-white
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硫前列酮性质、用途与生产工艺
硫前列酮为前列腺素E2类似物,具有较强的子宫收缩作用,且作用较长,并具有较好的软化和扩张子宫颈管的作用。临床用于抗早孕、中期引产、扩宫颈及堕死胎等。
Sulprostone (SHB 286) 是一种有效的,选择性的 EP3 受体激动剂。Sulprostone (SHB 286) 是一种前列腺素 E2 (PGE2) 类似物,具有抗溃疡和非甾体类抗流产作用。Sulprostone 有潜力用于终止妊娠和分娩时的出血。
Sulprostone (SHB 286) has K
i
values of 21 nM and 0.6 nM for EP1 and EP3 in cultured Chinese hamster ovary cells.
Sulprostone (1, 1.5 or 2 mg/mL) does not significantly modify the viability and the purity of Dendritic cells (DCs). Sulprostone impairs spontaneous and directed DC migration independently from its concentration. Sulprostone reduces the expression of CCR7 and impairs migration of DCs.
Sulprostone (SHB 286; 0.5 mg/kg; IV) has a T
1/2
of 0.451 hours, a CL of 56 mL/min•kg, a V
ss
of 0.583 L/kg and an AUC of 149 ng•h/mL.
Animal Model:
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Male cynomolgus monkey
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Dosage:
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0.5 mg/kg (Pharmacokinetic Analysis)
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Administration:
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IV
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Result:
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Had a T
1/2
of 0.451 hours, a CL of 56 mL/min•kg, a V
ss
of 0.583 L/kg and an AUC of 149 ng•h/mL.
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硫前列酮
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硫前列酮
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60325-46-4, 硫前列酮 相关搜索:
- 小分子
- 医药原料药
- Forensic and Veterinary Standards
- Drug Standards
- Chromatography
- Analytical Standards
- Analytical Chromatography Product Catalog
- C23H31NO7S
- 舒普洛司通
- 硫前列酮/SULPROSTONE
- 化合物 T23404
- (Z)-7-[(1R,2R,3R)-3-羟基-2-((E,3R)-3-羟基-4-苯氧基-1-丁烯基)-5-氧代环戊基]-N-甲基磺酰基-5-庚烯酰胺
- 素普罗斯顿
- 硫前列酮
- 60325-46-4
- Sulprostone in 5mg/ml Methyl Acetate
- 5-Heptenamide, 7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3R)-3-hydroxy-4-phenoxy-1-buten-1-yl]-5-oxocyclopentyl]-N-(methylsulfonyl)-, (5Z)-
- Sulprostone >=95% (HPLC), oil
- Sulprostone USP/EP/BP
- (Z)-7-[(1R,2R,3R)-3-Hydroxy-2-[(E,3R)-3-hydroxy-4-(phenoxy)but-1-enyl]-5-oxocyclopentyl]-N-methylsulfonylhept-5-enamide
- (5z,11α,13e,15r)-11,15-dihydroxy-9-oxo-16-phenoxy-17,18,19,20-tetranorprosta-5,13-dienoic acid methane sulfonamide
- (5Z)-7-[(1R,2R,3R)-3-Hydroxy-2-[(1E,3R)-3-hydroxy-4-buten-1-yl]-5-oxocyclopentyl]-N-(methylsulfonyl)-5-heptenamide
- CP-34086
- Nalador
- (5Z,11a,13E,15R)--11,15-Dihydroxy-9-oxo-16-phenoxy-17,18,19,20-tetranorprosta-5,13-dienoic acid methane sulfonamide
- CP-34089, SHB-286, ZK-57671, (5Z,11α,13E,15R)--11,15-Dihydroxy-9-oxo-16-phenoxy-17,18,19,20-tetranorprosta-5,13-dienoic acid methane sulfonamide
- (5Z,11alpha,13E,15R)-11,15-Dihydroxy-9-oxo-16-phenoxy-17,18,19,20-tetranor-prosta-5Z,13E-dien-1-amide
- CP-34089
- (5Z,11ALPHA,13E,15R)-11,15-DIHYDROXY-9-OXO-16-PHENOXY-17,18,19,20-TETRANORPROSTA-5,13-DIENOIC ACID METHANE SULFONAMIDE
- sch286
- 5-heptenamide,7-(3-hydroxy-2-(3-hydroxy-4-phenoxy-1-butenyl)-5-oxocyclopentyl)
- ZK-57671
- SULPROSTONE
- SHB-286
- N-(METHYLSULFONYL)-9-OXO-11ALPHA,15R-DIHYDROXY-16-PHENOXY-17,18,19,20-TETRANOR-PROSTA-5Z,13E-DIEN-1-AMIDE
- 16-phenoxy-omega-17,18,19,20-tetranorprostaglandine2methylsulfonylamide
- 16-phenoxy-omega-17,18,19,20-tetranorpge-2methylsulfonylamide
- 16-phenoxy-17,18,19,20tetranorprostaglandine(sub2)methylsulfonylamide
- (1r-(1-alpha(z),2-beta(1e,3r*),3-alpha))--n-(methylsulfonyl)