4-氨基己-5-烯酸
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- CAS号:
- 68506-86-5
- 英文名:
- (±)-4-aminohex-5-enoic acid
- 英文别名:
- CPP 109;rac-Vigabatrin;(+/-)-Vigabatrin;Vigabatrin (1712001);SABRIL; Γ-VINYL-GABA;5-Hexenoic acid, 4-amino-;Vigabatrin, racemic mixture;(±)-4-aminohex-5-enoic acid;rac-VigabatrinDiscontinued See V253010;Vigabatrin hydrochloride salt, racemic mixture
- 中文名:
- 4-氨基己-5-烯酸
- 中文别名:
- 维加巴林;氨己烯酸杂质;4-氨基己-5-烯酸
- CBNumber:
- CB3877472
- 分子式:
- C6H11NO2
- 分子量:
- 129.16
- MOL File:
- 68506-86-5.mol
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4-氨基己-5-烯酸化学性质
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熔点:
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209℃
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沸点:
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277.7±28.0 °C(Predicted)
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密度:
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1.064±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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Methanol (Slightly), Water (Slightly)
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酸度系数(pKa):
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4.36±0.10(Predicted)
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颜色:
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Off-White
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水溶解性:
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Soluble to 100 mM in water
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4-氨基己-5-烯酸性质、用途与生产工艺
Vigabatrin (γ-Vinyl-GABA)，一种抑制性神经递质 GABA 乙烯基衍生物，是一种具有口服活性且不可逆的 GABA 转氨酶 (GABA transaminase) 抑制剂。 Vigabatrin 是一种抗癫痫剂，通过抑制 GABA transaminase 对 GABA 的分解代谢来增加脑中 GABA 的水平。
A significant increase in seizure threshold is observed following systemic (i.p.) administration of high (600 or 1200 mg/kg) doses of Vigabatrin. Bilateral microinjection of Vigabatrin (10 μg) into either the anterior or posterior substantia nigra pars reticulata (SNr) also increased seizure threshold, but less markedly than systemic treatment. Focal delivery into the subthalamic nucleus (STN) increased seizure threshold more markedly than either intranigral or systemic administration of Vigabatrin.
Vigabatrin inhibits the uptake of taurine in Caco-2 and MDCK cells to 34% and 53%, respectively, at a concentration of 30 mM. In Caco-2 cells the uptake of Vigabatrin under neutral pH conditions is concentration-dependent and saturable with a Km-value of 27 mM. Vigabatrin is able to inhibit the uptake of taurine in intestinal and renal cell culture models.
4-氨基己-5-烯酸
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68506-86-5, 4-氨基己-5-烯酸 相关搜索:
- 膜转运
- 离子通道
- 维加巴林
- 氨己烯酸杂质
- 4-氨基己-5-烯酸
- 68506-86-5
- rac-Vigabatrin
- Vigabatrin (1712001)
- Vigabatrin hydrochloride salt, racemic mixture
- Vigabatrin, racemic mixture
- (+/-)-Vigabatrin
- rac-VigabatrinDiscontinued See V253010
- SABRIL; Γ-VINYL-GABA
- 5-Hexenoic acid, 4-amino-
- CPP 109
- (±)-4-aminohex-5-enoic acid