4-氨基己-5-烯酸
| 中文名称 | 4-氨基己-5-烯酸 |
|---|---|
| 中文同义词 | 4-氨基己-5-烯酸;氨己烯酸杂质;维加巴林 |
| 英文名称 | (±)-4-aminohex-5-enoic acid |
| 英文同义词 | (±)-4-aminohex-5-enoic acid;CPP 109;5-Hexenoic acid, 4-amino-;SABRIL; Γ-VINYL-GABA;rac-VigabatrinDiscontinued See V253010;(+/-)-Vigabatrin;Vigabatrin, racemic mixture;Vigabatrin hydrochloride salt, racemic mixture |
| CAS号 | 68506-86-5 |
| 分子式 | C6H11NO2 |
| 分子量 | 129.16 |
| EINECS号 | 270-929-6 |
| 相关类别 | 离子通道;膜转运 |
| Mol文件 | 68506-86-5.mol |
| 结构式 |  |
4-氨基己-5-烯酸 性质
| 熔点 | 209℃ |
|---|---|
| 沸点 | 277.7±28.0 °C(Predicted) |
| 密度 | 1.064±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 甲醇（微溶）、水（微溶） |
| 酸度系数(pKa) | 4.36±0.10(Predicted) |
| 颜色 | 米白色 |
| 水溶解性 | Soluble to 100 mM in water |
A significant increase in seizure threshold is observed following systemic (i.p.) administration of high (600 or 1200 mg/kg) doses of Vigabatrin. Bilateral microinjection of Vigabatrin (10 μg) into either the anterior or posterior substantia nigra pars reticulata (SNr) also increased seizure threshold, but less markedly than systemic treatment. Focal delivery into the subthalamic nucleus (STN) increased seizure threshold more markedly than either intranigral or systemic administration of Vigabatrin.
Vigabatrin inhibits the uptake of taurine in Caco-2 and MDCK cells to 34% and 53%, respectively, at a concentration of 30 mM. In Caco-2 cells the uptake of Vigabatrin under neutral pH conditions is concentration-dependent and saturable with a Km-value of 27 mM. Vigabatrin is able to inhibit the uptake of taurine in intestinal and renal cell culture models.
安全信息
| 危险品标志 | Xi |
|---|---|
| 危险类别码 | 36/37/38 |
| 安全说明 | 26-36 |
| WGK Germany | 3 |
| RTECS号 | MP7745000 |
| 海关编码 | 2922498050 |
| 毒害物质数据 | 68506-86-5(Hazardous Substances Data) |
| 毒性 | LD50 oral in rat: 3gm/kg |