PSEUROTIN A
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- CAS号:
- 58523-30-1
- 英文名:
- pseurotin
- 英文别名:
- PB-1;pseurotin;NSC 348694;(5S,8S,9R)-8-benzoyl-2-[(Z,1S,2S)-1,2-dihydroxyhex-3-enyl]-9-hydroxy-8-methoxy-3-methyl-1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione;(5S,8S,9R)-8-Benzoyl-2-[(1S,2S,3Z)-1,2-dihydroxy-3-hexenyl]-9-hydroxy-8-methoxy-3-methyl-1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione;1-Oxa-7-azaspiro[4.4]non-2-ene-4,6-dione, 8-benzoyl-2-[(1S,2S,3Z)-1,2-dihydroxy-3-hexen-1-yl]-9-hydroxy-8-methoxy-3-methyl-, (5S,8S,9R)-
- 中文名:
- PSEUROTIN A
- 中文别名:
- CBNumber:
- CB41326785
- 分子式:
- C22H25NO8
- 分子量:
- 431.44
- MOL File:
- 58523-30-1.mol
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PSEUROTIN A化学性质
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熔点:
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126.0-126.9℃
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沸点:
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751.5±60.0 °C(Predicted)
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密度:
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1.41±0.1 g/cm3(Predicted)
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储存条件:
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-20°C
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溶解度:
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Soluble in DMSO (10 mg/ml)
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酸度系数(pKa):
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14.76±0.20(Predicted)
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形态:
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White to off-white powder.
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颜色:
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White
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稳定性:
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Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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PSEUROTIN A性质、用途与生产工艺
Pseurotin A，曲霉和其他真菌的次级代谢产物，是几丁质合成酶 (chitin synthase) 的竞争性抑制剂和神经发生剂。Pseurotin A 抑制 IgE 的产生 (IC50=3.6 μM)。Pseurotin A 具有抗肿瘤活性。
Pseurotin A inhibits the expression of PCSK9 in HepG2 cells, with an IC
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value of 1.2 μM. Pseurotin A (25-100 μM; 72 hours) significantly suppressed the PCSK9 level in a dose dependent manner in BT-474 and T47D BC cell lines. Pseurotin A (25-100 μM; 72 hours) significantly increases LDLR level in a dose dependent manner.
Pseurotin A (40-200 μM; 24-72 hours) shows anti-proliferative activity in the hormone-dependent BC cells.
Cell Viability Assay
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Cell Line:
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BT-474 cells, T47D cells
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Concentration:
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40-200 μM
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Incubation Time:
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24-72 hours
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Result:
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Showed weak but time and dose-dependent inhibition of the growth of BT-474 and T47D BC cells, with gradual decrease of the IC
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values over time (260.83-93.64 μM and 267.84-113.08 μM, respectively).
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Pseurotin A (10 mg/kg; p.o.; 7X/week, 30 days) shows anti-tumor activity.
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Animal Model:
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HFD-fed orthotopic athymic mice (bearing BT-474 tumor cells xenograft mode)
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Dosage:
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10 mg/kg
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Administration:
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P.o.; 7X/week, 30 days
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Result:
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Significantly suppressed the growth of BT474 tumors.
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PSEUROTIN A
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-138648 | PB1 | | 1 mg | 1727元 |
| 2024/04/30 | HY-138648 | PSEUROTIN A
PB1 | 58523-30-1 | 5mg | 3800元 |
58523-30-1, PSEUROTIN A 相关搜索:
- 生物碱
- 微生物代谢物
- 58523-30-1
- (5S,8S,9R)-8-benzoyl-2-[(Z,1S,2S)-1,2-dihydroxyhex-3-enyl]-9-hydroxy-8-methoxy-3-methyl-1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione
- 1-Oxa-7-azaspiro[4.4]non-2-ene-4,6-dione, 8-benzoyl-2-[(1S,2S,3Z)-1,2-dihydroxy-3-hexen-1-yl]-9-hydroxy-8-methoxy-3-methyl-, (5S,8S,9R)-
- NSC 348694
- PB-1
- (5S,8S,9R)-8-Benzoyl-2-[(1S,2S,3Z)-1,2-dihydroxy-3-hexenyl]-9-hydroxy-8-methoxy-3-methyl-1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione
- pseurotin