WYE 354-d3

CAS号:: 1794791-66-4

英文名:: WYE 354-d3

英文别名:: WYE 354-d3;4-[6-[4-[[(Methoxy-d3)carbonyl]aMino]phenyl]-4-(4-Morpholinyl)-1H-pyrazolo[3,4-d]pyriMidin-1-yl]-1-piperidinecarboxylic Acid Methyl Ester

中文名:: WYE 354-d3

中文别名:

CBNumber:: CB42551409

分子式:: C24H29N7O5

分子量:: 495.54

MOL File:: 1794791-66-4.mol

化学性质安全信息用途供应商 10

WYE 354-d3化学性质

安全信息

WYE 354-d3性质、用途与生产工艺

用途

A labelled pyrazolopyrimidines derivative that is a potent and ATP-competitive mTOR inhibitor with much reduced activity against PI 3-Kα or PI 3-Kγ. WYE-354 is equally potent against mTORC1 and mTORC2 activities in HEK293 immune complex kinase assays using S6K and Akt as the respective substrate (IC50 <200 nM; [ATP] = 100 μM) and effectively blocks cellular phosphorylation of S6K on T389 and Akt o n S473 both in cultures and in a murine xenograft model, resulting in a significant suppression of PC3MM2-derived tumor growth (by 86% on day 7; 50 mg/kg, i.p twice per day) in vivo.

WYE 354-d3 上下游产品信息

上游原料

下游产品

WYE 354-d3 生产厂家

全球有 10家供应商 WYE 354-d3国内生产厂家

供应商	联系电话	电子邮件	国家	产品数	优势度
凯试(上海)科技有限公司	021-50135380	shchemsky@sina.com	中国	15421	60
安耐吉化学&3A（安徽泽升科技有限公司）	021-58432009 400-005-6266	marketing1@energy-chemical.com	中国	44843	58

1794791-66-4, WYE 354-d3 相关搜索:

4-[6-[4-[(甲氧羰基)氨基]苯基]-4-(4-吗啉基)-1H-吡唑并[3,4-D]嘧啶-1-基]-1-哌啶羧酸甲酯 N-[4-[1-(1,4-二氧杂螺[4.5]癸烷-8-基)-4-(8-氧杂-3-氮杂双环[3.2.1]辛烷-3-基)-1H-吡唑并[3,4-D]嘧啶-6-基]苯基]-N'-甲基脲 N-[4-[4-(4-吗啉基)-1-[1-(3-吡啶甲基)-4-哌啶基]-1H-吡唑并[3,4-D]嘧啶-6-基]苯基]氨基甲酸甲酯

Protein Kinase Inhibitors and Activators
Pharmaceuticals
Isotope Labelled Compounds
Intermediates & Fine Chemicals
Heterocycles
Aromatics
Amines
C24H26D3N7O5
1794791-66-4
4-[6-[4-[[(Methoxy-d3)carbonyl]aMino]phenyl]-4-(4-Morpholinyl)-1H-pyrazolo[3,4-d]pyriMidin-1-yl]-1-piperidinecarboxylic Acid Methyl Ester
WYE 354-d3