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WYE 354-d3

WYE 354-d3 Structure
WYE 354-d3 structure
CAS No.
1794791-66-4
Chemical Name:
WYE 354-d3
Synonyms
WYE 354-d3;4-[6-[4-[[(Methoxy-d3)carbonyl]aMino]phenyl]-4-(4-Morpholinyl)-1H-pyrazolo[3,4-d]pyriMidin-1-yl]-1-piperidinecarboxylic Acid Methyl Ester
CBNumber:
CB42551409
Molecular Formula:
C24H29N7O5
Molecular Weight:
495.54
MDL Number:
MOL File:
1794791-66-4.mol
Last updated:2022-09-15 14:44:07
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WYE 354-d3 price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC W950002 WYE354-d3 1794791-66-4 10mg $1760 2021-12-16 Buy
Product number Packaging Price Buy
W950002 10mg $1760 Buy

WYE 354-d3 Chemical Properties,Uses,Production

Uses

A labelled pyrazolopyrimidines derivative that is a potent and ATP-competitive mTOR inhibitor with much reduced activity against PI 3-Kα or PI 3-Kγ. WYE-354 is equally potent against mTORC1 and mTORC2 activities in HEK293 immune complex kinase assays using S6K and Akt as the respective substrate (IC50 <200 nM; [ATP] = 100 μM) and effectively blocks cellular phosphorylation of S6K on T389 and Akt on S473 both in cultures and in a murine xenograft model, resulting in a significant suppression of PC3MM2-derived tumor growth (by 86% on day 7; 50 mg/kg, i.p twice per day) in vivo.

WYE 354-d3 Preparation Products And Raw materials

Raw materials

Preparation Products

WYE 354-d3 Suppliers

Global( 10)Suppliers
Supplier Tel Email Country ProdList Advantage
Chemsky (shanghai) International Co.,Ltd 021-50135380 shchemsky@sina.com China 15421 60
Energy Chemical 021-58432009 400-005-6266 marketing1@energy-chemical.com China 44843 58
Supplier Advantage
Chemsky (shanghai) International Co.,Ltd 60
Energy Chemical 58

1794791-66-4(WYE 354-d3)Related Search:

WYE-354 N-[4-[1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methylurea WYE-687
WYE 354-d3 4-[6-[4-[[(Methoxy-d3)carbonyl]aMino]phenyl]-4-(4-Morpholinyl)-1H-pyrazolo[3,4-d]pyriMidin-1-yl]-1-piperidinecarboxylic Acid Methyl Ester 1794791-66-4 C24H26D3N7O5 Amines Aromatics Heterocycles Intermediates & Fine Chemicals Isotope Labelled Compounds Pharmaceuticals Protein Kinase Inhibitors and Activators