乙氧苯噻唑胺
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- CAS号:
- 452-35-7
- 英文名:
- 6-ETHOXY-2-BENZOTHIAZOLESULFONAMIDE
- 英文别名:
- U-4191;Cardrase;Ethamide;mingoral;L-643786;PNU-4191;diureticc;Diuretic C;Redupresin;Etoxzolamide
- 中文名:
- 乙氧苯噻唑胺
- 中文别名:
- 依索唑胺;乙氧苯噻唑胺
- CBNumber:
- CB4401490
- 分子式:
- C9H10N2O3S2
- 分子量:
- 258.32
- MOL File:
- 452-35-7.mol
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乙氧苯噻唑胺化学性质
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熔点:
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190-193 °C(lit.)
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沸点:
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464.9±37.0 °C(Predicted)
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密度:
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1.4767 (rough estimate)
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折射率:
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1.6800 (estimate)
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储存条件:
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Refrigerator
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溶解度:
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DMSO (Slightly), Ethyl Acetate (Slightly)
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酸度系数(pKa):
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pKa 8.12(H2O t=25.0) (Uncertain)
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形态:
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Solid
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颜色:
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Off-White
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水溶解性:
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10.33mg/L(25 ºC)
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Merck:
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13,3790
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乙氧苯噻唑胺性质、用途与生产工艺
乙氧苯噻唑胺在临床上除了有弱的利尿作用外，临床主要用于治疗青光眼，脑水肿，癫痫发作以及高原缺氧导致水肿性疾病和消化性溃疡。
Ethoxzolamide 是 carbonic anhydrase 的抑制剂，其 Ki 值为 1 nM。
Ki: 1 nM (carbonic anhydrase)
Ethoxzolamide (ETZ) treatment causes >90% inhibition of reporter GFP fluorescence in infected macrophages. Moreover, in a 9-day macrophage survival assay, Ethoxzolamide (ETZ) treatment significantly inhibits the ability of
M. tuberculosis
to grow intracellularly.
It is discovered that the lipid-soluble ethoxzolamide is converted in vivo to a water-soluble metabolite, while retaining high activity againstt the enzyme. At the minimal dose for maximal effect (4 mg/kg i.v. at 45 min) the IOP lowering is 4.2 mmHg, the concentration in anterior uvea is 2.5 pmol/kg, and the fractional inhibition of the enzyme (i) is 0.9995. The effect declines rapidly, attributable to the very short half-life of drug in plasma, leading to depletion of free drug in the anterior uvea and other tissues. Ethoxzolamide (ETZ) strongly downregulates GFP reporter fluorescence in mouse lungs, with 3-fold inhibition of GFP signal compare to that in the mock-treating control. There is a significant reduction of bacterial survival in the lungs of ETZ-treating mice compare to the mock-treating control.
乙氧苯噻唑胺
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-B1480 | 乙氧苯噻唑胺
Ethoxzolamide | 452-35-7 | 100mg | 1700元 |
| 2024/04/30 | HY-B1480 | 乙氧苯噻唑胺
Ethoxzolamide | 452-35-7 | 10mM * 1mLin DMSO | 1870元 |
452-35-7, 乙氧苯噻唑胺 相关搜索:
- ANTIZOL
- Building Blocks
- Thiazoles
- Heterocyclic Building Blocks
- C9H10N2O3S2
- 乙氧苯噻唑胺
- 依索唑胺
- 452-35-7
- Carbonate dehydratase,L 643786,inhibit,Inhibitor,Bacterial,PNU 4191,PNU4191,L643786,Carbonic Anhydrase,Ethoxzolamide
- Ethoxzolamide (1265005)
- 6-ETHOXY-2-BENZOTHIAZOLESULFONAMIDE USP/EP/BP
- PNU-4191
- L-643786
- 6-ethoxybenzo[d]thiazole-2-sulfonaMide
- Ethoxzolamide (200 mg)
- 6-Ethoxyzolamide, Ethoxzolamide
- 6-Ethoxy-2-benzothiazole8ulfonamide
- 6-ethoxybenzothiazole-2-sulphonamide
- 6-ethoxybenz[d]thiazole-2-sulfonamide
- U-4191
- Redupresin
- mingoral
- Glaucotensil
- Etoxzolamide
- Ethoxyzolamide
- Ethoxazolamide
- Ethamide
- diureticc
- Diuretic C
- Cardrase
- 6-Ethoxybenzothiazole-2-sulfonamide
- 6-ethoxy-2-benzothiazolesulfonamid
- 6-Ethoxy-1,3-benzothiazole-2-sulfonamide
- 2-Benzothiazolesulfonamide, 6-ethoxy-
- ETHOXZOLAMIDE
- 6-ETHOXY-2-BENZOTHIAZOLESULFONAMIDE
- 6-ETHOXYZOLAMIDE