硝替卡朋
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- CAS号:
- 116313-94-1
- 英文名:
- Nitecapone
- 英文别名:
- OR 462;Nitecapone;3-(3,4-dihydroxy-5-nitrobenzylidene)pentane-2,5-dione;3-(3,4-Dihydroxy-5-nitrobenzylidene)pentane-2,4-dione;3-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-2,4-pentanedione;2,4-Pentanedione, 3-[(3,4-dihydroxy-5-nitrophenyl)methylene]-;GSH,Nitecapone,glutathione,OR-462,Inhibitor,ROS,Parkinson,COMT,OR 462,inhibit,OR462,allodynia
- 中文名:
- 硝替卡朋
- 中文别名:
- 硝替卡朋
- CBNumber:
- CB51176592
- 分子式:
- C12H11NO6
- 分子量:
- 265.22
- MOL File:
- 116313-94-1.mol
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硝替卡朋化学性质
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熔点:
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171-173°C
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沸点:
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495.3±45.0 °C(Predicted)
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密度:
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1.451±0.06 g/cm3(Predicted)
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储存条件:
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Sealed in dry,Store in freezer, under -20°C
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溶解度:
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DMSO: soluble15mg/mL, clear
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形态:
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powder
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酸度系数(pKa):
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5.60±0.50(Predicted)
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颜色:
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white to beige
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硝替卡朋性质、用途与生产工艺
硝替卡朋(OR-462) 是一种药物，可作为儿茶酚 O-甲基转移酶 (COMT) 的选择性抑制剂。它已获得抗帕金森药物专利。
硝替卡朋可用作儿茶酚-O-甲基转移酶(COMT)抑制剂。
Nitecapone (OR-462) 是一个短效的、具有口服活性的、儿茶酚-O-甲基转移酶 (COMT) 的抑制剂，具有胃肠道保护和抗氧化活性。Nitecapone (OR-462) 可清除活性氧和一氧化氮，防止脂质过氧化。
Nitecapone (1-100 μM) reducesd GSH (reduced glutathione) depletion induced by ROO
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by 11-38% and oxidation to oxidized glutathione (GSSG) by 32-45%.
Nitecapone (30 mg/kg, ip daily for 13 days) reduces development and symptoms of neuropathic pain after spinal nerve ligation in rats.
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Animal Model:
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Eighty-six male Wistar rats, weighing 140-350 g.
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Dosage:
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30 mg/kg (3.3 mL/kg).
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Administration:
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IP, once daily for 13 days.
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Result:
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Selectively and specifically inhibits COMT in the peripheral tissues, and to some extent in the CNS for ca. 3 h.
Increased the thresholds for the mechanical stimuli and thus reduced mechanical allodynia.
Reduced the number of positive reactions of the ipsilateral paws when compared with the baselines in the nitecapone-pretreated rats.
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硝替卡朋
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-106842 | 硝替卡朋
Nitecapone | 116313-94-1 | 5mg | 800元 |
| 2024/04/30 | HY-106842 | Nitecapone | | 10 mM * 1 mLin DMSO | 880元 |
116313-94-1, 硝替卡朋 相关搜索:
- Aromatics
- Pharmaceuticals
- Intermediates & Fine Chemicals
- 硝替卡朋
- 116313-94-1
- 2,4-Pentanedione, 3-[(3,4-dihydroxy-5-nitrophenyl)methylene]-
- GSH,Nitecapone,glutathione,OR-462,Inhibitor,ROS,Parkinson,COMT,OR 462,inhibit,OR462,allodynia
- 3-(3,4-dihydroxy-5-nitrobenzylidene)pentane-2,5-dione
- 3-(3,4-Dihydroxy-5-nitrobenzylidene)pentane-2,4-dione
- OR 462
- Nitecapone
- 3-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-2,4-pentanedione