2-[(5-氯-8-喹啉基)氧基]乙酸乙酯
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- CAS号:
- 88349-90-0
- 英文名:
- ST072042
- 英文别名:
- A2793;ST072042;ethyl 2-(5-chloroquinolin-8-yl)oxyacetate;ethyl [(5-chloroquinolin-8-yl)oxy]acetate;ethyl 2-[(5-chloro-8-quinolyl)oxy]acetate;ethyl 2-(5-chloroquinolin-8-yl)oxyethanoate;2-[(5-chloro-8-quinolyl)oxy]acetic acid ethyl ester;Acetic acid, 2-[(5-chloro-8-quinolinyl)oxy]-, ethyl ester;A2793,inhibit,Inhibitor,A-2793,TALK-1,TRESK,pain,KcsA,TASK-1,A 2793,Potassium Channel
- 中文名:
- 2-[(5-氯-8-喹啉基)氧基]乙酸乙酯
- 中文别名:
- 2-((5-氯喹啉-8-基)氧基)乙酸乙酯;2-[(5-氯-8-喹啉基)氧基]乙酸乙酯
- CBNumber:
- CB53056845
- 分子式:
- C13H12ClNO3
- 分子量:
- 265.69
- MOL File:
- 88349-90-0.mol
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2-[(5-氯-8-喹啉基)氧基]乙酸乙酯化学性质
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沸点:
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393.4±27.0 °C(Predicted)
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密度:
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1.291±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 100 mg/mL (376.38 mM)
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酸度系数(pKa):
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1.97±0.29(Predicted)
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2-[(5-氯-8-喹啉基)氧基]乙酸乙酯性质、用途与生产工艺
A2793 (Ethyl [(5-Chloroquinolin-8-yl)oxy]acetate) 是 TWIK-related spinal cord potassium channel (TRESK, K2P18, KCNK18) 和 TASK-1 (KCNK3),对于小鼠TRESK的IC50值为6.8 μM。
Target | Value |
mTRESK
(Cell-free assay)
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6.8 μM
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A2793 (100 µM) inhibits the unstimulated channel by 43.0±8.9% (n=5) while after ionomycin activation the reduction of the TRESK current is 85.5±2.9% (n=5).
A2793 inhibits TASK-1 (100 µM, 53.4±13,5%, n=5), while A2764 is more selective for TRESK, it only moderately influences
TREK-1 and TALK-1.
A2793 may be considered as a tool to discriminate between the resting and activated channels in heterologous expression systems, and to block TRESK activated by calcineurin in the native cells which do not express TASK-1.
2-[(5-氯-8-喹啉基)氧基]乙酸乙酯
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-137563 | A2793 | | 1 mg | 571元 |
2024/01/25 | HY-137563 | 2-[(5-氯-8-喹啉基)氧基]乙酸乙酯 A2793 | 88349-90-0 | 5mg | 1350元 |
2-[(5-氯-8-喹啉基)氧基]乙酸乙酯
生产厂家
88349-90-0, 2-[(5-氯-8-喹啉基)氧基]乙酸乙酯 相关搜索:
- 药靶配体
- 制剂-抑制剂
- 2-((5-氯喹啉-8-基)氧基)乙酸乙酯
- 2-[(5-氯-8-喹啉基)氧基]乙酸乙酯
- 88349-90-0
- A2793,inhibit,Inhibitor,A-2793,TALK-1,TRESK,pain,KcsA,TASK-1,A 2793,Potassium Channel
- A2793
- Acetic acid, 2-[(5-chloro-8-quinolinyl)oxy]-, ethyl ester
- ST072042
- ethyl 2-[(5-chloro-8-quinolyl)oxy]acetate
- ethyl 2-(5-chloroquinolin-8-yl)oxyethanoate
- ethyl 2-(5-chloroquinolin-8-yl)oxyacetate
- ethyl [(5-chloroquinolin-8-yl)oxy]acetate
- 2-[(5-chloro-8-quinolyl)oxy]acetic acid ethyl ester