2-[(5-氯-8-喹啉基)氧基]乙酸乙酯
| 中文名称 | 2-[(5-氯-8-喹啉基)氧基]乙酸乙酯 |
|---|---|
| 中文同义词 | 2-[(5-氯-8-喹啉基)氧基]乙酸乙酯;2-((5-氯喹啉-8-基)氧基)乙酸乙酯 |
| 英文名称 | ST072042 |
| 英文同义词 | 2-[(5-chloro-8-quinolyl)oxy]acetic acid ethyl ester;ethyl [(5-chloroquinolin-8-yl)oxy]acetate;ethyl 2-(5-chloroquinolin-8-yl)oxyacetate;ethyl 2-(5-chloroquinolin-8-yl)oxyethanoate;ethyl 2-[(5-chloro-8-quinolyl)oxy]acetate;ST072042;Acetic acid, 2-[(5-chloro-8-quinolinyl)oxy]-, ethyl ester;A2793 |
| CAS号 | 88349-90-0 |
| 分子式 | C13H12ClNO3 |
| 分子量 | 265.69 |
| EINECS号 | |
| 相关类别 | 制剂-抑制剂 |
| Mol文件 | 88349-90-0.mol |
| 结构式 | ![2-[(5-氯-8-喹啉基)氧基]乙酸乙酯 结构式](CAS/GIF/88349-90-0.gif) |
2-[(5-氯-8-喹啉基)氧基]乙酸乙酯 性质
| 沸点 | 393.4±27.0 °C(Predicted) |
|---|---|
| 密度 | 1.291±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：100 mg/mL（376.38 mM） |
| 酸度系数(pKa) | 1.97±0.29(Predicted) |
A2793 (Ethyl [(5-Chloroquinolin-8-yl)oxy]acetate) 是 TWIK-related spinal cord potassium channel (TRESK, K2P18, KCNK18) 和 TASK-1 (KCNK3)，对于小鼠TRESK的IC50值为6.8 μM。
| Target | Value |
|
mTRESK
(Cell-free assay) | 6.8 μM |
A2793 (100 µM) inhibits the unstimulated channel by 43.0±8.9% (n=5) while after ionomycin activation the reduction of the TRESK current is 85.5±2.9% (n=5).
A2793 inhibits TASK-1 (100 µM, 53.4±13,5%, n=5), while A2764 is more selective for TRESK, it only moderately influences
TREK-1 and TALK-1.
A2793 may be considered as a tool to discriminate between the resting and activated channels in heterologous expression systems, and to block TRESK activated by calcineurin in the native cells which do not express TASK-1.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-137563 | A2793 | 1 mg | 571元 | |
| 2024/04/30 | HY-137563 | 2-[(5-氯-8-喹啉基)氧基]乙酸乙酯 A2793 | 88349-90-0 | 5mg | 1350元 |