L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE

生物活性靶点体外研究体内研究

CAS号:: 159190-45-1

英文名:: L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE

英文别名:: L-NIL HCL;L-NIL DIHYDROCHLORIDE;L-N6-(1-Iminoethyl)lysine;OQIBCXRAFAHXMM-KLXURFKVSA-N;L-N6-(1-IMINOETHYL)-LYSINE 2HCL;L-N6-(1-IMINOETHYL)LYSINE, DIHCL;L-Lysine ω-acetamidine dihydrochloride;L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE;LNIL dihydrochloride,L NIL dihydrochloride;N6-(1-IMINOETHYL)-L-LYSINE DIHYDROCHLORIDE

中文名:: L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE

中文别名:: 化合物 T25749;L-N6-(1-亚氨基乙基)赖氨酸二盐酸盐;L-N⁶-(1-亚氨乙基)赖氨酸二盐酸盐

CBNumber:: CB5353543

分子式:: C8H18ClN3O2

分子量:: 223.7

MOL File:: 159190-45-1.mol

化学性质安全信息用途供应商 25

L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE化学性质

储存条件:: -20°C

溶解度:: DMF: 15 mg/mL; DMSO: 15 mg/mL; Ethanol: 1 mg/mL; PBS: 30 mg/mL; Water: 50 mg/ml

形态:: White to off-white solid.

安全信息

危险品标志:	Xi

危险类别码:	36/37/38

安全说明:	37/39-26-36

WGK Germany:	3

L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE性质、用途与生产工艺

生物活性

L-NIL dihydrochloride 是诱导型一氧化氮合成酶 (iNOS) 的抑制剂，其对 miNOS 的 IC50 值为3.3 μM。

靶点

IC50: 3.3 μM (mouse inducible NO synthase), 92 μM (rat brain constitutive NO synthase).

L-NIL produces a concentration-dependent inhibition of both the mouse inducible NOS (miNOS) and the rat brain constitutive NOS (rcNOS) and is considerably more potent for miNOS. The IC ₅₀ values for L-NIL with miNOS and rcNOS are 3.3 and 92 pM, respectively, indicating that L-NIL is 28-fold more selective for miNOS. In addition, L-NIL has approximately 6-fold greater potency for miNOS than either L-NMA or L-NNA.

体内研究

L-NIL (10 and 30 mg/kg, IP) prevents the inflammation, oxidative stress and autophagy induced by renal IR in mice.

Animal Model:	Adult male Balb/c (20-25 g).
Dosage:	10 and 30 mg/kg.
Administration:	Intraperitoneally at the end of CLP and at 6 h after sepsis induction.
Result:	Led to a negligible increase in plasma NGAL compared to sham mice. Led to a significant decrease in both TLR4 and IL1βprotein contents and clusterin transcript. Showed an increase in NFAT5 mRNA levels, as compared with mice treated with vehicle. Promoted a decrease in AR protein expression, as compared with animals treated with vehicle.

L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE 上下游产品信息

上游原料

下游产品

L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE 生产厂家

全球有 25家供应商 L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE国内生产厂家

供应商	联系电话	电子邮件	国家	产品数	优势度
上海阿拉丁生化科技股份有限公司	400-400-6206333 18521732826	market@aladdin-e.com	中国	25014	65
Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司	021-61415566 800-8193336	orderCN@merckgroup.com	中国	51471	80
上海一飞生物科技有限公司	021-65675885 18964387627	info@efebio.com	中国	9709	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	美国	19892	58
江苏洪珉药业有限公司	18221292452	fannieliu@glschina.com	中国	6799	58
ChemeGen 中国	18818260767	sales@chemegen.com	中国	11289	58
安耐吉化学&3A（安徽泽升科技有限公司）	021-58432009 400-005-6266	marketing@energy-chemical.com	中国	44941	58
上海优宁维生物科技股份有限公司	18768175414	gaojun@univ-bio.com	中国	24998	58
TargetMol中国（陶术生物）	4008200310	marketing@tsbiochem.com	中国	24017	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	美国	57511	58

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Nitric Oxide
高端化学
Biochemicals and Reagents
BioChemical
L to O
Enzymes, Inhibitors, and Substrates
Enzyme Inhibitors by Enzyme
Enzyme Inhibitors
Nitric Oxide Synthase
L-N6-(1-亚氨基乙基)赖氨酸二盐酸盐
L-N⁶-(1-亚氨乙基)赖氨酸二盐酸盐
化合物 T25749
159190-45-1
LNIL dihydrochloride,L NIL dihydrochloride
L-N6-(1-Iminoethyl)lysine
OQIBCXRAFAHXMM-KLXURFKVSA-N
L-NIL DIHYDROCHLORIDE
L-Lysine ω-acetamidine dihydrochloride
L-Lysine, N6-(1-iMinoethyl)-, (Hydrochloride) (1:2)
N6-(1-IMINOETHYL)-L-LYSINE DIHYDROCHLORIDE
L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE
L-N6-(1-IMINOETHYL)LYSINE, DIHCL
L-N6-(1-IMINOETHYL)-LYSINE 2HCL
L-NIL HCL